| Gene Symbol |
RPA3
|
| Entrez Gene |
6119
|
| Alt Symbol |
REPA3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
replication protein A3, 14kDa
|
| Other Description |
RF-A protein 3|RP-A p14|replication factor A protein 3|replication protein A 14 kDa subunit
|
| Swissprots |
Q549U6 P35244
|
| Accessions |
AAQ96878 AAX84517 EAL24304 EAW93603 EAW93604 EAW93605 P35244 AK311842 BAG34784 BC005264 AAH05264 BC009868 AAH09868 BT007320 AAP35984 L07493 AAA58350 NM_002947 NP_002938
|
| Function |
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Plays also a role in b
|
| Subcellular Location |
Nucleus.
|
| Top Pathways |
DNA replication, Mismatch repair, Homologous recombination, Nucleotide excision repair, Fanconi anemia pathway
|