ENPP2

Gene Symbol	ENPP2
Entrez Gene	5168
Alt Symbol	ATX, ATX-X, AUTOTAXIN, LysoPLD, NPP2, PD-IALPHA, PDNP2
Species	Human
Gene Type	protein-coding
Description	ectonucleotide pyrophosphatase/phosphodiesterase 2
Other Description	E-NPP 2|autotaxin-t|ectonucleotide pyrophosphatase/phosphodiesterase family member 2|extracellular lysophospholipase D|phosphodiesterase I/nucleotide pyrophosphatase 2|plasma lysophospholipase D
Swissprots	Q15117 A8UHA1 Q13827 Q9UCR0 Q14555 Q13822 Q9UCR4 E9PHP7 Q9UCR1 Q9UCR3 Q9UCR2 Q9UCQ8
Accessions	AAB00855 BAA08342 CCF77047 CCF77048 CCF77049 CCQ43347 EAW91986 EAW91987 EAW91988 EAW91989 EAW91990 Q13822 AA256687 AI339551 AI375195 AK124910 AK130313 AK296027 BAG58795 AK315253 AL544867 BC034961 AAH34961 BM694754 BQ365938 BU731264 CA390514 D45421 BAA08260 DA919550 DA922156 DB468753 DC338843 DQ891628 ABM82554 DQ894819 ABM85745 EU131011 ABW38316 L35594 AAA64785 XM_006716584 XP_006716647 XM_006716585 XP_006716648 XM_006716586 XP_006716649 XM_006716587 XP_006716650 NM_001040092 NP_001035181 NM_001130863 NP_001124335 NM_006209 NP_006200 NR_045555
Function	Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility- related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor. {ECO:0000269|PubMed:11559573, ECO:0000269|PubMed:1733949, ECO:0000269|PubMed:21240271}.
Subcellular Location	Secreted {ECO:0000269|PubMed:15769751}. Note=Secreted by most body fluids including serum and CSF. Also by adipocytes and numerous cancer cells.
Tissue Specificity	Predominantly expressed in brain, placenta, ovary, and small intestine. Expressed in a number of carcinomas such as hepatocellular and prostate carcinoma, neuroblastoma and non-small-cell lung cancer. Expressed in body fluids such as plasma, cerebral spinal fluid (CSF), saliva, follicular and amniotic fluids. Not detected in leukocytes. Isoform 1 is more highly expressed in peripheral tissues than in the central nervous system (CNS). Adipocytes only express isoform 1. Isoform 3 is more highly expressed in the brain than in peripheral tissues. {ECO:0000269|PubMed:18175805, ECO:0000269|PubMed:8579579, ECO:0000269|PubMed:8586446}.
Top Pathways	Ether lipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human ENPP2 protein fragment - ab191673 from Abcam Category Protein Prices $597.00 Sizes 50 µg Source HEK 293 cells Species Human

Human ENPP2 full length protein - ab126918 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

ENPP2 / Autotaxin Antibody Blocking Peptide - LS-E7151 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ENPP2 / Autotaxin Antibody Blocking Peptide - LS-E7152 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ENPP2 / Autotaxin Antibody Blocking Peptide - LS-E16489 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ENPP2-Antibody-Center-Blocking-Peptide - BP2854d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ENPP2-Antibody-Center-K416-Blocking-Peptide - BP2854c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human ENPP-2/Autotaxin, CF - 5255-EN-010 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Asp49-Ile863, with an N-terminal 6-His tag

Human ATX protein - orb138756 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 10 μg, 20 μg Source Human Cells Species Human

ENPP2 Blocking Peptide - 33R-10264 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human ENPP2 Protein - abx066385 from Abbexa Category Protein Source E.coli Species Human

Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2), Human - 20-8450 from ARP American Research Products Category Protein Prices $589.00 Sizes 50 µg Source E.coli Species Human

Autotaxin Recombinant Protein - 96-264 from ProSci Category Protein Prices $425.00 Sizes 50 µg Source HEK293 cells Species Human

ENPP2 fusion protein - ag5499 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human ENPP2, GST-tagged - ENPP2-6998H from Creative Biomart Category Protein Source Sf9 Cells Species Human

Recombinant Human ENPP2, His tagged - ENPP2-570H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human ENPP2, His-tagged - ENPP2-3123H from Creative Biomart Category Protein Source HEK293 Species Human

Recombinant Human ENPP2, His-tagged - ENPP2-566H from Creative Biomart Category Protein Source Sf9.

Recombinant Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) - RPC323Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) - RPC323Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Human Autotaxin / ENPP2 / NPP2 Protein (His Tag) - 11308-H07H-10 from Sino Biological Category Protein Source Human Cells Species Human

ENPP2 protein-GST fusion - 009-001-R89 from Rockland Immunochemicals Inc Category Protein Prices $499.00 Sizes 50 µg Species Human

ENPP2 protein-GST fusion - 009-001-R89S from Rockland Immunochemicals Inc Category Protein Prices $265.00 Sizes 20 µg Species Human

Recombinant Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) - RPC323Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Ectonucleotide pyrophosphatase/phosphodiesterase family member 2(ENPP2) ,partial - CSB-YP613427HU CSB-EP613427HU CSB-BP613427HU CSB-MP613427HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

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