Gene Symbol | HABP2 |
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Entrez Gene | 3026 |
Alt Symbol | FSAP, HABP, HGFAL, PHBP |
Species | Human |
Gene Type | protein-coding |
Description | hyaluronan binding protein 2 |
Other Description | factor VII activating protein|factor VII-activating protease|factor seven-activating protease|hepatocyte growth factor activator-like protein|hyaluronan-binding protein 2|hyaluronic acid binding protein 2|plasma hyaluronan binding protein|plasma hyaluronan-binding protein |
Swissprots | O00663 F5H5M6 B7Z8U5 A8K467 Q14520 |
Accessions | AAS16352 EAW49505 Q14520 AK290832 BAF83521 AK303759 BAH14041 AK303761 BAH14042 AK303948 BAH14081 BC031412 AAH31412 D49742 BAA08576 DC413026 DQ890820 ABM81746 DQ893975 ABM84901 S83182 AAB46909 NM_001177660 NP_001171131 NM_004132 NP_004123 |
Function | Cleaves the alpha-chain at multiple sites and the beta- chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro- urokinase) to the active two chain form. Activates coagulation factor VII. {ECO:0000269|PubMed:10754382, ECO:0000269|PubMed:11217080, ECO:0000269|PubMed:8827452}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:8827452}. Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form. |
Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:8827452}. |
HABP2 CRISPR/Cas9 KO Plasmid (h) - sc-407713 from Santa Cruz Biotechnology
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HABP2 HDR Plasmid (h) - sc-407713-HDR from Santa Cruz Biotechnology
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HABP2 Double Nickase Plasmid (h) - sc-407713-NIC from Santa Cruz Biotechnology
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HABP2 Double Nickase Plasmid (h2) - sc-407713-NIC-2 from Santa Cruz Biotechnology
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HABP2 CRISPR Activation Plasmid (h) - sc-407713-ACT from Santa Cruz Biotechnology
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HABP2 CRISPR Activation Plasmid (h2) - sc-407713-ACT-2 from Santa Cruz Biotechnology
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HABP2 Lentiviral Activation Particles (h) - sc-407713-LAC from Santa Cruz Biotechnology
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HABP2 Lentiviral Activation Particles (h2) - sc-407713-LAC-2 from Santa Cruz Biotechnology
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HABP2 siRNA (h) - sc-90485 from Santa Cruz Biotechnology
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HABP2 shRNA Plasmid (h) - sc-90485-SH from Santa Cruz Biotechnology
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HABP2 shRNA (h) Lentiviral Particles - sc-90485-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU051611 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2196 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2196 from Sigma-Aldrich
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HABP2 siRNA (Human) - CRH2056 from Cohesion Biosciences
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HABP2 RNAi - H00003026-R01 from Novus Biologicals
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HABP2 - MBS8207661 from MyBioSource
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shRNA set against Human HABP2 (NM_004132.3) - SHH310089 from Creative biogene
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HABP2 shRNA Plasmid (Human) - CHH2056 from Cohesion Biosciences
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HABP2 miRNA 3'UTR clone - MiUTR3H-06386 from Creative biogene
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