Hsp90ab1
| Gene Symbol | Hsp90ab1 |
|---|---|
| Entrez Gene | 301252 |
| Alt Symbol | HSP90-BETA, HSP90B, HSPC2, Hspcb |
| Species | Rat |
| Gene Type | protein-coding |
| Description | heat shock protein 90 alpha (cytosolic), class B member 1 |
| Other Description | HSP 84|HSP84|heat shock 84 kDa|heat shock 90kDa protein 1, beta|heat shock protein 90kDa alpha (cytosolic), class B member 1|heat shock protein HSP 90-beta |
| Swissprots | Q1PSW2 P34058 Q9QWC6 Q66H55 Q68GV5 |
| Accessions | ABE27999 P34058 AY695392 AAT99568 AY695393 AAT99569 AY724481 BC082009 AAH82009 FQ223952 FQ225238 FQ225402 FQ227008 FQ231832 FQ233497 S45392 AAB23369 NM_001004082 NP_001004082 |
| Function | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:8663025}. Melanosome {ECO:0000250}. |
| Top Pathways | Progesterone-mediated oocyte maturation, Prostate cancer, NOD-like receptor signaling pathway, Protein processing in endoplasmic reticulum, PI3K-Akt signaling pathway |
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