Gene Symbol | HYAL2 |
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Entrez Gene | 8692 |
Alt Symbol | LUCA2 |
Species | Human |
Gene Type | protein-coding |
Description | hyaluronoglucosaminidase 2 |
Other Description | PH-20 homolog|PH20 homolog|hyal-2|hyaluronidase 2|hyaluronidase-2|hyaluronoglucosaminidase-2|lung carcinoma protein 2|lysosomal hyaluronidase |
Swissprots | Q12891 Q9BW29 B3KRZ2 O15177 |
Accessions | AAB67045 EAW65092 EAW65093 EAW65094 Q12891 AF070608 AAC28656 AJ000099 CAA03924 AJ844619 CAH59903 AJ844620 CAH59742 AK092449 BAG52554 AK127945 BAG54602 AK225635 AK310963 BC000692 AAH00692 BU626745 DB033601 DC358776 DC384113 DQ893838 ABM84764 EU176170 ABW03621 U09577 AAC62823 XM_005265524 XP_005265581 XM_005265525 XP_005265582 NM_003773 NP_003764 NM_033158 NP_149348 |
Function | Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R. {ECO:0000269|PubMed:11296287, ECO:0000269|PubMed:12676986, ECO:0000269|PubMed:9712871}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:11296287}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11296287}. |
Tissue Specificity | Widely expressed. No expression detected in adult brain. {ECO:0000269|PubMed:9712871}. |
Top Pathways | Glycosaminoglycan degradation |
HYAL2 CRISPR/Cas9 KO Plasmid (h) - sc-405005 from Santa Cruz Biotechnology
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HYAL2 HDR Plasmid (h) - sc-405005-HDR from Santa Cruz Biotechnology
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HYAL2 Double Nickase Plasmid (h) - sc-405005-NIC from Santa Cruz Biotechnology
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HYAL2 Double Nickase Plasmid (h2) - sc-405005-NIC-2 from Santa Cruz Biotechnology
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HYAL2 CRISPR Activation Plasmid (h) - sc-405005-ACT from Santa Cruz Biotechnology
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HYAL2 CRISPR Activation Plasmid (h2) - sc-405005-ACT-2 from Santa Cruz Biotechnology
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HYAL2 Lentiviral Activation Particles (h) - sc-405005-LAC from Santa Cruz Biotechnology
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HYAL2 Lentiviral Activation Particles (h2) - sc-405005-LAC-2 from Santa Cruz Biotechnology
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HYAL2 siRNA (h) - sc-60824 from Santa Cruz Biotechnology
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HYAL2 shRNA Plasmid (h) - sc-60824-SH from Santa Cruz Biotechnology
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HYAL2 shRNA (h) Lentiviral Particles - sc-60824-V from Santa Cruz Biotechnology
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HYAL2 RNAi - H00008692-R04 from Novus Biologicals
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HYAL2 RNAi - H00008692-R03 from Novus Biologicals
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MISSION® esiRNA - EHU067081 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10411 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10411 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02222 from Sigma-Aldrich
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HYAL2 siRNA (Human) - CRH5720 from Cohesion Biosciences
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HYAL2 - MBS8210183 from MyBioSource
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shRNA set against Human HYAL2 (NM_003773.4) - SHH316161 from Creative biogene
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shRNA set against Human HYAL2(NM_033158.4) - SHH136955 from Creative biogene
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Human HYAL2 siRNA - orb266222 from Biorbyt
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HYAL2 shRNA Plasmid (Human) - CHH5720 from Cohesion Biosciences
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HYAL2 miRNA 3'UTR clone - MiUTR1H-04765 from Creative biogene
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HYAL2 miRNA 3'UTR clone - MiUTR3H-06068 from Creative biogene
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