| Gene Symbol |
TNFAIP3
|
| Entrez Gene |
7128
|
| Alt Symbol |
A20, OTUD7C, TNFA1P2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tumor necrosis factor, alpha-induced protein 3
|
| Other Description |
OTU domain-containing protein 7C|TNF alpha-induced protein 3|putative DNA-binding protein A20|tumor necrosis factor alpha-induced protein 3|tumor necrosis factor inducible protein A20|zinc finger protein A20
|
| Swissprots |
P21580 E1P588 Q9NSR6 Q5VXQ7 Q2HIX9 B2R767
|
| Accessions |
AAO61093 CBY94061 EAW47923 EAW47924 EAW47925 EAW47926 P21580 AK312862 BAG35714 AL157444 CAB75664 AY820830 AAV71149 BC041790 BC064689 BC098379 BC113871 AAI13872 BC114480 AAI14481 BQ002744 CB528739 DB143089 FJ434402 ACN87230 FJ434405 ACN87231 FJ434406 ACN87232 FJ434407 ACN87233 FJ434408 ACN87234 FJ434409 ACN87235 FJ434410 ACN87236 FJ434411 ACN87237 FJ434412 ACN87238 FJ434413 ACN87239 FJ434414 ACN87240 FJ434415 ACN87241 FJ434417 ACN87242 FJ434418 ACN87243 FJ434419 ACN87244 HY009939 HY085289 M59465 AAA51550 XM_005267119 XP_005267176 XM_006715555 XP_006715618 XM_011536095 XP_011534397 XM_011536096 XP_011534398 NM_001270507 NP_001257436 NM_001270508 NP_001257437 NM_006290 NP_006281
|
| Function |
Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termi
|
| Subcellular Location |
Cytoplasm. Nucleus. Lysosome.
|
| Top Pathways |
NOD-like receptor signaling pathway, Measles, Epstein-Barr virus infection, TNF signaling pathway
|