| Gene Symbol | Robo1 |
|---|---|
| Entrez Gene | 58946 |
| Alt Symbol | - |
| Species | Rat |
| Gene Type | protein-coding |
| Description | roundabout, axon guidance receptor, homolog 1 (Drosophila) |
| Other Description | roundabout homolog 1 |
| Swissprots | O55005 |
| Accessions | O55005 AF041082 AAC39960 XM_008768533 XP_008766755 XM_008768534 XP_008766756 XM_008768535 XP_008766757 XM_008768536 XP_008766758 NM_022188 NP_071524 |
| Function | Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development (By similarity). {ECO:0000250}. |
| Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Tissue Specificity | Expressed in embryonal brain and spinal chord. {ECO:0000269|PubMed:10102268, ECO:0000269|PubMed:9458045}. |
| Top Pathways | Axon guidance |