Gene Symbol | CPSF3L |
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Entrez Gene | 54973 |
Alt Symbol | CPSF73L, INT11, INTS11, RC-68, RC68 |
Species | Human |
Gene Type | protein-coding |
Description | cleavage and polyadenylation specific factor 3-like |
Other Description | CPSF3-like protein|cleavage and polyadenylation-specific factor 3-like protein|integrator complex subunit 11|protein related to CPSF subunits of 68 kDa|related to CPSF subunits 68 kDa |
Swissprots | Q9H8R5 Q5TA45 Q5TA48 G3V1S5 Q5TA54 Q7L3D7 Q5TA53 A8K5S2 Q9BW36 B4DM87 Q5TA46 Q9HAA6 Q9NWX9 Q96HY1 B3KPR3 Q9H0F9 Q5TA52 |
Accessions | EAW56232 EAW56233 EAW56234 EAW56235 EAW56236 EAW56237 EAW56238 EAW56239 EAW56240 EAW56241 EAW56242 EAW56243 EAW56244 Q5TA45 AA687684 AK000549 BAA91246 AK021939 BAB13943 AK022675 AK023356 BAB14541 AK027767 AK056652 BAG51775 AK058018 AK092190 AK123641 AK291387 BAF84076 AK297350 BAG59799 AL136813 CAB66747 AM393218 CAL38096 BC000675 AAH00675 BC007978 AAH07978 BC008041 AAH08041 BC013904 AAH13904 BC020199 AAH20199 BC042444 BC047576 BK005673 DAA05669 BK005728 DAA05728 CR533557 CAG38588 DC295791 DC299237 DC299993 KF274554 XM_011541647 XP_011539949 XM_011541648 XP_011539950 XM_011541649 XP_011539951 XM_011541650 XP_011539952 XR_426614 NM_032179 NM_001256456 NP_001243385 NM_001256460 NP_001243389 NM_001256462 NP_001243391 NM_001256463 NP_001243392 NM_017871 NP_060341 |
Function | Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. {ECO:0000269|PubMed:16239144}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:15684398}. Cytoplasm {ECO:0000269|PubMed:15684398}. |
CPSF3L CRISPR/Cas9 KO Plasmid (h) - sc-417238 from Santa Cruz Biotechnology
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CPSF3L HDR Plasmid (h) - sc-417238-HDR from Santa Cruz Biotechnology
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CPSF3L Double Nickase Plasmid (h) - sc-417238-NIC from Santa Cruz Biotechnology
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CPSF3L Double Nickase Plasmid (h2) - sc-417238-NIC-2 from Santa Cruz Biotechnology
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CPSF3L CRISPR Activation Plasmid (h) - sc-417238-ACT from Santa Cruz Biotechnology
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CPSF3L CRISPR Activation Plasmid (h2) - sc-417238-ACT-2 from Santa Cruz Biotechnology
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CPSF3L Lentiviral Activation Particles (h) - sc-417238-LAC from Santa Cruz Biotechnology
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CPSF3L Lentiviral Activation Particles (h2) - sc-417238-LAC-2 from Santa Cruz Biotechnology
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CPSF3L siRNA (h) - sc-88083 from Santa Cruz Biotechnology
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CPSF3L shRNA Plasmid (h) - sc-88083-SH from Santa Cruz Biotechnology
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CPSF3L shRNA (h) Lentiviral Particles - sc-88083-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU156751 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6525 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6525 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01681 from Sigma-Aldrich
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CPSF3L siRNA (Human) - CRJ0372 from Cohesion Biosciences
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CPSF3L - MBS8213503 from MyBioSource
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shRNA set against Human CPSF3L (NM_017871.5) - SHH268945 from Creative biogene
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Human CPSF3L siRNA - orb270873 from Biorbyt
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CPSF3L shRNA Plasmid (Human) - CHJ0372 from Cohesion Biosciences
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CPSF3L miRNA 3'UTR clone - MiUTR3H-11826 from Creative biogene
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