| Gene Symbol |
UGT2A3
|
| Entrez Gene |
79799
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
UDP glucuronosyltransferase 2 family, polypeptide A3
|
| Other Description |
UDP-glucuronosyltransferase 2A3|UDPGT 2A3
|
| Swissprots |
Q9H6S4 Q6UWM9
|
| Accessions |
EAX05580 EAX05581 Q6UWM9 AK025587 BAB15179 AK225308 AK293381 BAG56893 AW194955 AY358727 AAQ89089 AY542891 AAS48425 BC130533 AAI30534 BP262099 HQ258456 ADR83210 XM_011532247 XP_011530549 XM_011546332 XP_011544634 NM_024743 NP_079019 NR_024010
|
| Function |
UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Top Pathways |
Chemical carcinogenesis, Steroid hormone biosynthesis, Pentose and glucuronate interconversions, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450
|