SMAD6

Gene Symbol SMAD6
Entrez Gene 4091
Alt Symbol AOVD2, HsT17432, MADH6, MADH7
Species Human
Gene Type protein-coding
Description SMAD family member 6
Other Description MAD homolog 6|SMAD, mothers against DPP homolog 6|mothers against decapentaplegic homolog 6|mothers against decapentaplegic, drosophila, homolog of, 6
Swissprots Q7Z7L4 Q15799 O43541 Q9UKZ3 A9J6M5 Q96E31 O43654
Accessions AAF06841 AAF14343 EAW77784 EAW77785 EAW77786 O43541 AF035528 AAB94137 AF037469 AAC82331 AF043640 AAC00497 AM909653 CAP20377 BC012986 AAH12986 BC029288 BC052569 BU154759 CA406301 CB055216 CN314453 CN314455 U59914 AAC50792 XM_011521561 XP_011519863 XR_931825 XR_931826 XR_931827 NM_005585 NP_005576 NR_027654 NM_001142861
Function Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions. {ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:16951688, ECO:0000269|PubMed:9436979}.
Subcellular Location Nucleus {ECO:0000269|PubMed:16491121}.
Tissue Specificity Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
Top Pathways TGF-beta signaling pathway, Endocytosis

Smad6 CRISPR/Cas9 KO Plasmid (h) - sc-401411 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smad6 HDR Plasmid (h) - sc-401411-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smad6 Double Nickase Plasmid (h) - sc-401411-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smad6 Double Nickase Plasmid (h2) - sc-401411-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smad6 CRISPR Activation Plasmid (h) - sc-401411-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smad6 CRISPR Activation Plasmid (h2) - sc-401411-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smad6 Lentiviral Activation Particles (h) - sc-401411-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smad6 Lentiviral Activation Particles (h2) - sc-401411-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smad6 siRNA (h) - sc-38380 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Smad6 shRNA Plasmid (h) - sc-38380-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Smad6 shRNA (h) Lentiviral Particles - sc-38380-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SMAD6 RNAi - H00004091-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN19754 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19754 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SMAD6 siRNA (Human) - CRH2774 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SMAD6 - MBS8204769 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SMAD6 (NM_005585.4) - SHH413008 from Creative biogene

Category siRNA
Species Reactivities Human

Human SMAD6 siRNA - orb263276 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SMAD6 shRNA Plasmid (Human) - CHH2774 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SMAD6 miRNA 3'UTR clone - MiUTR3H-05424 from Creative biogene

Species Reactivities Human
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