NPC1L1

Gene Symbol NPC1L1
Entrez Gene 29881
Alt Symbol NPC11L1
Species Human
Gene Type protein-coding
Description NPC1-like 1
Other Description NPC1 (Niemann-Pick disease, type C1, gene)-like 1|Niemann-Pick C1-like protein 1
Swissprots D3DVK9 A4D2J7 Q6R3Q4 Q17RV5 B7ZLE6 Q9UHC8 Q9UHC9
Accessions EAL23753 EAW61096 EAW61097 EAW61098 Q9UHC9 AF192522 AAF20396 AF192523 AAF20397 AY437865 AAR97886 AY515256 AAS56939 AY927603 BC117178 AAI17179 BC143731 BC143756 AAI43757 FJ481111 ACL18055 XM_011515326 XP_011513628 XM_011515327 XP_011513629 XM_011515328 XP_011513630 NM_001101648 NP_001095118 NM_001300967 NP_001287896 NM_013389 NP_037521
Function Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down- regulates its expression and secretion by inhibiting its maturation and accelerating its degradation. {ECO:0000269|PubMed:15928087, ECO:0000269|PubMed:22095670}.
Subcellular Location Apical cell membrane {ECO:0000269|PubMed:15671032}; Multi-pass membrane protein {ECO:0000269|PubMed:15671032}. Cell membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:15671032}; Multi-pass membrane protein {ECO:0000269|PubMed:15671032}. Note=Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein (By similarity). According to PubMed:15671032, localizes in a subcellular vesicular compartment rich in RAB5. {ECO:0000250}.
Tissue Specificity Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle. {ECO:0000269|PubMed:10783261, ECO:0000269|PubMed:14976318, ECO:0000269|PubMed:15671032}.
Top Pathways Fat digestion and absorption

NPC1L1 Antibody - 5058 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Hep G2 and MKN-45 cells using NPC1L1 Antibody.

NPC1L1 (G-1) - sc-166802 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NPC1L1 (G-1): sc-166802. Western blot analysis of NPC1L1 expression in HeLa whole cell lysate.

NPC1L1 (H-240) - sc-67236 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

NPC1L1 (N-13) - sc-49063 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NPC1L1 (N-13): sc-49063. Western blot analysis of NPC1L1 expression in Hep G2 (A), Caco-2 (B), MIA PaCa-2 (C) and HeLa (D) whole cell lysates.

NPC1L1 (M-220) - sc-67237 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-Niemann Pick C1 Like 1 antibody - ab121000 from Abcam

Prices $242.00
Sizes 200 µl
Host Goat
Clonality Polyclonal

Anti-Niemann Pick C1 Like 1 antibody [EPR5717] - ab124801 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5717
All lanes : Anti-Niemann Pick C1 Like 1 antibody [EPR5717] (ab124801) at 1/1000 dilutionLane 1 : Human fetal liver lysatesLane 2 : HeLa lysatesLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-Niemann Pick C1 Like 1 antibody - N-terminal - ab156410 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Niemann Pick C1 Like 1 antibody - N-terminal (ab156410) at 1/100 dilution + 293 cell lysate at 35 µg

Anti-NPC1L1 Antibody (Internal, clone EPR5717) - LS-C138967 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5717
IHC of paraffin-embedded human liver tissue using anti-NPC1L1 antibody.

Anti-NPC1L1 Antibody (aa1000-1100) IHC-plus™ - LS-B88 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-NPC1L1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B88 concentration 20 ug/ml.

Anti-NPC1L1 Antibody (aa500-600) IHC-plus™ - LS-B506 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-NPC1L1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B506 concentration 20 ug/ml.

Anti-NPC1L1 Antibody (Internal) IHC-plus™ - LS-B9450 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-NPC1L1 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-NPC1L1 Antibody (Internal) - LS-C73566 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NPC1L1 Antibody (Internal, HRP) - LS-C142067 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NPC1L1 Antibody (Internal, DY550) - LS-C142068 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NPC1L1 Antibody - LS-C131053 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NPC1L1 Antibody (Internal, Biotin) - LS-C142069 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NPC1L1 Antibody (Internal, DY650) - LS-C142070 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NPC1L1 Antibody (Internal, Biotin) - LS-C142172 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NPC1L1 Antibody (Internal, DY650) - LS-C142173 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NPC1L1 Antibody (Internal, DY488) - LS-C142175 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NPC1L1 Antibody (Internal, DY488) - LS-C142174 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NPC1L1 Antibody (Internal, DY550) - LS-C142177 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NPC1L1 Antibody (Internal, HRP) - LS-C142176 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NPC1L1 Antibody (aa1288-1300) - LS-C154844 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
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