| Gene Symbol | MORF4L1 |
|---|---|
| Entrez Gene | 10933 |
| Alt Symbol | Eaf3, FWP006, HsT17725, MEAF3, MORFRG15, MRG15, S863-6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | mortality factor 4 like 1 |
| Other Description | Esa1p-associated factor 3 homolog|MORF-related gene 15 protein|MORF-related gene on chromosome 15|mortality factor 4-like protein 1|protein MSL3-1|transcription factor-like protein MRG15 |
| Swissprots | Q9NSW5 O95899 Q5QTS1 D3DW88 Q86YT7 B4DKN6 Q6NVX8 B7Z6R1 Q9UBU8 Q9HBP6 |
| Accessions | EAW99144 EAW99145 EAW99146 EAW99147 Q9UBU8 AF070664 AAD20970 AF100615 AAD29872 AF109188 AAQ13497 AF131847 AAD20058 AF161546 AAF29033 AF167173 AAF80854 AF218011 AAG17253 AK095823 BAG53140 AK098485 AK296650 BAG59248 AK300789 BAH13347 AK310181 AK310592 AK310702 AL137697 CAB70879 AY148481 AAN65338 BC002936 AAH02936 BC022845 AAH22845 BC067826 AAH67826 BC121092 AAI21093 BC121093 AAI21094 BC141840 AAI41841 BG771854 BM996530 BX382045 CX165647 DB455429 DQ892602 ABM83528 DQ895837 ABM86763 NM_001265603 NP_001252532 NM_001265604 NP_001252533 NM_001265605 NP_001252534 NM_006791 NP_006782 NM_206839 NP_996670 |
| Function | Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair |
| Subcellular Location | Nucleus. |