INPP5D

Gene Symbol	INPP5D
Entrez Gene	3635
Alt Symbol	SHIP, SHIP-1, SHIP1, SIP-145, hp51CN, p150Ship
Species	Human
Gene Type	protein-coding
Description	inositol polyphosphate-5-phosphatase, 145kDa
Other Description	SH2 domain-containing inositol 5'-phosphatase 1|inositol polyphosphate-5-phosphatase, 145kD|phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1|signaling inositol polyphosphate 5 phosphatase SIP-145|signaling inositol polyphosphate phosphatase SHIP II
Swissprots	Q92656 Q6P5A4 Q13544 O00145 Q13545 Q92835 Q9UE80
Accessions	EAW71029 EAW71030 EAW71031 Q92835 AK298651 BAG60823 AK309644 AW503130 BC027960 BC062985 AAH62985 BC099920 AAH99920 BC113580 AAI13581 BC113582 AAI13583 BE247227 BM800110 U50040 AAC50453 U50041 AAC50454 U53470 AAD00081 U57650 AAB53573 U84400 AAB49680 X98429 CAA67071 XM_011511128 XP_011509430 XM_011511129 XP_011509431 XM_011548851 XP_011547153 XM_011548852 XP_011547154 NM_001017915 NP_001017915 NM_005541 NP_005532
Function	Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regul
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:10822173}. Membrane {ECO:0000269|PubMed:10822173}; Peripheral membrane protein {ECO:0000269|PubMed:10822173}. Note=Translocates to the plasma membrane when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. Partly translocated via its SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as the FC-gamma-RIIB receptor (FCGR2B) or CD16/FCGR3. Tyrosine phosphorylation may also participate in membrane localization (By similarity). {ECO:0000250}.
Tissue Specificity	Specifically expressed in immune and hematopoietic cells. Expressed in bone marrow and blood cells. Levels vary considerably within this compartment. Present in at least 74% of immature CD34+ cells, whereas within the more mature population of CD33+ cells, it is present in only 10% of cells. Present in the majority of T-cells, while it is present in a minority of B-cells (at protein level). {ECO:0000269|PubMed:8769125, ECO:0000269|PubMed:8874179, ECO:0000269|PubMed:9058707, ECO:0000269|PubMed:9108392}.
Top Pathways	B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Inositol phosphate metabolism, Phosphatidylinositol signaling system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat INPP5D / SHIP1 / SHIP ELISA Kit (Cell-Based ELISA) - LS-F2305 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 78-5000 pg/ml

Mouse/Human/Rat Phospho-INPP5D / SHIP1 / SHIP (Tyr1021) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1280 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 78-5000 pg/ml

Human INPP5D / SHIP1 / SHIP ELISA Kit (Sandwich ELISA) - LS-F12600 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 78 Range 78-5000 pg/ml

Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1, INPP5D, Human, ELISA Kit - E8909h from ARP American Research Products Category ELISA Kit Prices $660.00 Sizes 96 t Range 78-5000 pg/mL

SHIP1 Colorimetric Cell-Based ELISA Kit - CB5629 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

SHIP1 (Phospho-Tyr1021) Colorimetric Cell-Based ELISA Kit - CBP1282 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Mouse INPP5D / SHIP1 / SHIP ELISA Kit (Custom ELISA) - LS-F20238 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 78-5000 pg/ml

Rat INPP5D / SHIP1 / SHIP ELISA Kit (Custom ELISA) - LS-F20239 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 78-5000 pg/ml

ELISA Kit for Inositol Polyphosphate-5-Phosphatase 145kDa (INPP5D) - SEM030Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 13.5pg/mL. Range 31.25-2000pg/mL The standard curve concentrations used for the ELISA’s were 2000pg/mL, 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL

ELISA Kit for Inositol Polyphosphate-5-Phosphatase 145kDa (INPP5D) - SEM030Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 13.5pg/mL. Range 31.25-2000pg/mL The standard curve concentrations used for the ELISA's were 2000pg/mL, 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL

SHIP1 ELISA Kit - DEIA-XYA1613 from Creative Diagnostics Category ELISA Kit

SHIP1 (Phospho-Tyr1021) ELISA Kit - DEIA-XYA1614 from Creative Diagnostics Category ELISA Kit

INPP5D - EKH4814 from Nordic BioSite Sensitivity 46.9pg/ml Range 78-5000pg/ml

INPP5D ELISA Kit (Human) (OKEH01875) - OKEH01875 from Aviva Systems Biology Category ELISA Kit Prices $450.00 Sizes 96 wells Sensitivity 0.155 ng/mL Range 0.31 - 20 ng/mL

Human INPP5D ELISA Kit - E019882 from Biobool Category ELISA Kit Sensitivity 13.5pg/mL.

Human Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 ELISA Kit - EK4851 from Signalway Antibody Category ELISA Kit Prices $659.00 Sizes 1x96t Sensitivity less than 0.21ng/mL Range 0.78-50 ng/mL

Human Phospho-SHIP1 (Y1020) ELISA - PEL-SHIP1-Y1020-1 from RayBiotech Category ELISA Kit

anti-SHIP-1 antibody - ARG53558 from Arigo Biolaboratories Category ELISA Kit

anti-SHIP-1 antibody [SHIP-01] - ARG63092 from Arigo Biolaboratories Category ELISA Kit

anti-SHIP-1 antibody [SHIP-02] - ARG63093 from Arigo Biolaboratories Category ELISA Kit

anti-SHIP-1 antibody (Ready-to-Use) - ARG53559 from Arigo Biolaboratories Category ELISA Kit

Inositol Polyphosphate-5-Phosphatase 145kDa, ELISA Kit - MBS2031949 from MyBioSource Category ELISA Kit Prices $410.00, $610.00, $830.00, $3,420.00, $6,200.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 13.5pg/mL. Range 31.2-2,000pg/mL. The standard curve concentrations used for the ELISA's were 2,000pg/mL, 1,000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.2pg/mL.

Phosphatidylinositol-3, 4, 5-trisphosphate 5-phosphatase 1, ELISA Kit - MBS9428677 from MyBioSource Category ELISA Kit Prices $605.00 Sizes 96 tests Sensitivity Less than 18pg/mL Range 0.312-20 ng/mL

Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1, ELISA Kit - MBS289808 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 78-5000 pg/mL

Human INPP5D / SHIP1 / SHIP ELISA Kit (Sandwich ELISA) - LS-F33658 from LifeSpan Bioscience Category ELISA Kit Sensitivity 46.9 Range 78-5000 pg/ml

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