Gene Symbol | PSMA6 |
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Entrez Gene | 5687 |
Alt Symbol | IOTA, PROS27, p27K |
Species | Human |
Gene Type | protein-coding |
Description | proteasome (prosome, macropain) subunit, alpha type, 6 |
Other Description | 27 kDa prosomal protein|PROS-27|macropain iota chain|macropain subunit iota|multicatalytic endopeptidase complex iota chain|prosomal P27K protein|proteasome iota chain|proteasome subunit alpha type-6|proteasome subunit iota |
Swissprots | B4DQR4 P60900 B4DXJ9 Q6IB60 P34062 B2R7J9 |
Accessions | AAG61139 EAW65876 EAW65877 P60900 AA090836 AK298920 BAG61026 AK302008 BAG63411 AK313011 BAG35846 AK316223 BAH14594 BC002979 AAH02979 BC017882 AAH17882 BC022354 AAH22354 BC023659 AAH23659 BC070137 AAH70137 BG701535 BQ009843 BU198521 BU657545 CR456944 CAG33225 D28434 BAA05800 DQ892346 ABM83272 DQ895551 ABM86477 HY028439 X59417 CAA42052 X61972 CAA43964 NM_001282232 NP_001269161 NM_001282233 NP_001269162 NM_001282234 NP_001269163 NM_002791 NP_002782 NR_104110 |
Function | The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. |
Subcellular Location | Cytoplasm. Nucleus. Cytoplasm, P-body {ECO:0000250}. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}. |
Top Pathways | Proteasome |
20S Proteasome α6 CRISPR/Cas9 KO Plasmid (h) - sc-402341 from Santa Cruz Biotechnology
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20S Proteasome α6 HDR Plasmid (h) - sc-402341-HDR from Santa Cruz Biotechnology
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20S Proteasome α6 Double Nickase Plasmid (h) - sc-402341-NIC from Santa Cruz Biotechnology
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20S Proteasome α6 Double Nickase Plasmid (h2) - sc-402341-NIC-2 from Santa Cruz Biotechnology
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20S Proteasome α6 CRISPR Activation Plasmid (h) - sc-402341-ACT from Santa Cruz Biotechnology
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20S Proteasome α6 CRISPR Activation Plasmid (h2) - sc-402341-ACT-2 from Santa Cruz Biotechnology
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20S Proteasome α6 Lentiviral Activation Particles (h) - sc-402341-LAC from Santa Cruz Biotechnology
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20S Proteasome α6 Lentiviral Activation Particles (h2) - sc-402341-LAC-2 from Santa Cruz Biotechnology
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20S Proteasome α6 siRNA (h) - sc-62884 from Santa Cruz Biotechnology
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20S Proteasome α6 shRNA Plasmid (h) - sc-62884-SH from Santa Cruz Biotechnology
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20S Proteasome α6 shRNA (h) Lentiviral Particles - sc-62884-V from Santa Cruz Biotechnology
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Proteasome 20S alpha 6 RNAi - H00005687-R01 from Novus Biologicals
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MISSION® esiRNA - EHU110621 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17593 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17593 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00250 from Sigma-Aldrich
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PSMA6 siRNA (Human) - CRH3834 from Cohesion Biosciences
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shRNA set against Human PSMA6 (NM_002791.1) - SHH385100 from Creative biogene
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Human PSMA6 siRNA - orb264336 from Biorbyt
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PSMA6 shRNA Plasmid (Human) - CHH3834 from Cohesion Biosciences
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PSMA6 miRNA 3'UTR clone - MiUTR1H-08375 from Creative biogene
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