| Gene Symbol |
RAB26
|
| Entrez Gene |
25837
|
| Alt Symbol |
V46133
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAB26, member RAS oncogene family
|
| Other Description |
Ras-related oncogene protein|ras-related protein Rab-26
|
| Swissprots |
Q6NXS7 B2RAA6 Q3L6K5 Q9ULW5
|
| Accessions |
EAW85550 EAW85551 EAW85552 Q9ULW5 AB027137 BAA84707 AF498952 AAM21100 AK308560 AK309666 AK314110 BAG36803 AY646153 AAU88191 BC007681 BC066913 AAH66913 CB242472 XM_011522448 XP_011520750 XM_011522449 XP_011520751 XM_011522450 XP_011520752 NM_001308053 NP_001294982 NM_014353 NP_055168
|
| Function |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland. {ECO:0000269|PubMed:20038531, ECO:0000269|PubMed:23105096}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000269|PubMed:23105096}; Lipid-anchor {ECO:0000269|PubMed:23105096}; Cytoplasmic side {ECO:0000269|PubMed:23105096}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305|PubMed:23105096}; Lipid-anchor {ECO:0000305|PubMed:23105096}; Cytoplasmic side {ECO:0000305|PubMed:23105096}. Note=Not localized at the plasma membrane (By similarity). Inhibition of S-geranylgeranyl cysteine formation abolishes membrane location. {ECO:0000250}.
|
| Tissue Specificity |
Predominantly expressed in brain.
|