| Gene Symbol | MAP7 |
|---|---|
| Entrez Gene | 9053 |
| Alt Symbol | E-MAP-115, EMAP115 |
| Species | Human |
| Gene Type | protein-coding |
| Description | microtubule-associated protein 7 |
| Other Description | MAP-7|dJ325F22.2 (microtubule-associated protein 7 (EMAP115, E-MAP-115))|ensconsin|epithelial microtubule-associated protein of 115 kDa |
| Swissprots | C9JPS0 Q9NY82 B7Z9U7 Q8TAU5 B7Z400 F5H1E2 B7Z290 E9PCP3 Q9NY83 Q7Z6S0 B7Z5S7 Q14244 |
| Accessions | EAW47944 EAW47945 EAW47946 EAW47947 Q14244 AB073649 AI344295 AJ242501 CAB88030 AJ242502 CAB88031 AJ420541 AK294461 BAH11776 AK295749 BAH12177 AK296483 BAH12369 AK296556 BAH12386 AK299355 BAH13013 AK307873 AK311114 AK311227 AK311234 AK311236 AK311270 AK312789 BAG35651 AK316062 BAH14433 AK316529 BAH14900 AL042021 BC025777 AAH25777 BF792432 CB162980 CD557798 DA329576 DA341792 DC325462 DC332469 DQ890946 ABM81872 DQ896812 ABM87811 X73882 CAA52086 XM_006715598 XP_006715661 XM_006715599 XP_006715662 XM_006715600 XP_006715663 XM_006715601 XP_006715664 XM_011536243 XP_011534545 XM_011536244 XP_011534546 XM_011536245 XP_011534547 XM_011536246 XP_011534548 NM_001198608 NP_001185537 NM_001198609 NP_001185538 NM_001198611 NP_001185540 NM_001198614 NP_001185543 NM_001198615 NP_001185544 NM_001198616 NP_001185545 NM_001198617 NP_001185546 NM_001198618 NP_001185547 NM_001198619 NP_001185548 NM_003980 NP_003971 |
| Function | Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}. |
| Subcellular Location | Cytoplasm, perinuclear region. Basolateral cell membrane. Cytoplasm, cytoskeleton. Note=Colocalized on microtubules. An intracellular redistribution is triggered during induction of keratinocyte terminal differentiation from microtubules with a perinuclear localization to cortical microtubules organized in spike-like bundles facing intercellular contacts. |
| Tissue Specificity | Expressed in the skin and cells of epithelial origin. Predominantly expressed in the suprabasal layers of the normal epidermis and relatively abundant in squamous cell carcinomas but barely detectable in basal cell carcinomas. {ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}. |