| Gene Symbol |
NRG1
|
| Entrez Gene |
3084
|
| Alt Symbol |
ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
neuregulin 1
|
| Other Description |
glial growth factor|heregulin, alpha (45kD, ERBB2 p185-activator)|neu differentiation factor|pro-NRG1|pro-neuregulin-1, membrane-bound isoform|sensory and motor neuron derived factor
|
| Swissprots |
Q8NFN2 Q8NFN1 Q7RTW0 E9PHH4 A8K1L2 Q15491 Q07110 Q12779 Q12781 Q02298 Q12784 B7Z4Z3 O14667 Q7RTV9 P98202 Q07111 Q12782 Q8NFN3 Q02299 Q7RTW2 A5YAK5 Q02297 Q12780 A5YAK4 Q7RTW1 Q9UPE3 Q12783
|
| Accessions |
AAM71137 AAM71139 AAM71140 DAA00040 DAA00041 DAA00042 DAA00043 DAA00044 DAA00045 DAA00046 DAA00047 DAA00048 EAW63407 EAW63408 EAW63409 EAW63410 EAW63411 EAW63412 EAW63413 EAW63414 EAW63415 EAW63416 EAW63417 EAW63418 EAW63419 Q02297 AB451331 BAG70145 AB451475 BAG70289 AF026146 AAD01795 AF176921 AAQ13665 AK097005 AK223435 BAD97155 AK289927 BAF82616 AK290730 BAF83419 AK293240 BAH11473 AK293270 BAH11479 AK298132 BAH12729 AY207002 AAO49724 BC006492 AAH06492 BC007675 AAH07675 BC064587 AAH64587 BC073871 AAH73871 BC144446 BC150609 AAI50610 BQ018711 BT007389 AAP36053 CN603652 CN603654 CR450288 CAG29284 DA805080 DC425692 EF372273 ABQ53539 EF372274 ABQ53540 EF372275 ABQ53541 EF372276 ABQ53542 EF372277 ABQ53543 EF517295 ABR13842 EF517296 ABR13843 EF517297 ABR13844 EU359055 ABY70644 EU363508 ABY66348 EU363509 ABY66349 EU363510 ABY66350 GQ983557 ADN85612 GQ983558 ADN85613 HG501045 L12260 AAB59622 L12261 AAB59358 L41827 AAC41764 M94165 AAA58638 M94166 AAA58639 M94167 AAA58640 M94168 AAA58641 S68256 U02325 AAA19950 U02326 AAA19951 U02327 AAA19952 U02328 AAA19953 U02329 AAA19954 U02330 AAA19955 XM_005273485 XP_005273542 XM_005273486 XP_005273543 XM_005273487 XP_005273544 XM_006716335 XP_006716398 XM_011544512 XP_011542814 XM_011544513 XP_011542815 XM_011544514 XP_011542816 NM_001159995 NP_001153467 NM_001159996 NP_001153468 NM_001159999 NP_001153471 NM_001160001 NP_001153473 NM_001160002 NP_001153474 NM_001160004 NP_001153476 NM_001160005 NP_001153477 NM_001160007 NP_001153479 NM_001160008 NP_001153480 NM_004495 NP_004486 NM_013956 NP_039250 NM_013957 NP_039251 NM_013958 NP_039252 NM_013959 NP_039253 NM_013960 NP_039254 NM_013962 NP_039256 NM_013964 NP_039258
|
| Function |
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. {ECO:0000269|PubMed:1348215, ECO:0000269|PubMed:7902537}.
|
| Subcellular Location |
Isoform 10: Membrane; Single-pass type I membrane protein. Note=May possess an internal uncleaved signal sequence.
|
| Tissue Specificity |
Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cells; in the nervous system it is expressed in spinal cord and brain. Also detected in adult heart, placenta, lung, liver, kidney, and pancreas. Isoform 10 is expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney. Type IV isoforms are brain-specific. {
|
| Top Pathways |
ErbB signaling pathway
|
