| Gene Symbol |
SNRPG
|
| Entrez Gene |
6637
|
| Alt Symbol |
SMG, Sm-G
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
small nuclear ribonucleoprotein polypeptide G
|
| Other Description |
sm protein G|small nuclear ribonucleoprotein G|snRNP-G
|
| Swissprots |
D6W5G6 Q15357 Q6IB86 P62308
|
| Accessions |
AAX81996 CAJ42776 EAW99817 EAW99818 P62308 BC000070 AAH00070 BC022432 AAH22432 BC035103 AAH35103 BC066302 AAH66302 BC070166 AAH70166 BC071880 AAH71880 BC106055 AAI06056 CR456918 CAG33199 HQ448664 ADQ33142 X85373 CAA59689 NM_003096 NP_003087
|
| Function |
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Appears to function in the U7 snRNP complex that is involved in histone 3'- end processing. {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:23333303}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:18984161}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
|
| Top Pathways |
Spliceosome
|
![Western Blot: SNRPG Overexpression Lysate (Adult Normal) [NBL1-16294] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SNRPG.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6287_SNRPG%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16294-img0002.jpg)