PTGDS

Gene Symbol	PTGDS
Entrez Gene	5730
Alt Symbol	L-PGDS, LPGDS, PDS, PGD2, PGDS, PGDS2
Species	Human
Gene Type	protein-coding
Description	prostaglandin D2 synthase 21kDa (brain)
Other Description	PGD2 synthase|beta-trace protein|cerebrin-28|glutathione-independent PGD synthase|glutathione-independent PGD synthetase|lipocalin-type prostaglandin D synthase|lipocalin-type prostaglandin-D synthase|prostaglandin D synthase|prostaglandin-D2 synthase|prostaglandin-H2 D-isomerase
Swissprots	Q5SQ10 Q9UCC9 Q7M4P3 P41222 B2R727 Q9UCD9 Q9UC22
Accessions	AAB51074 ABB84464 EAW88321 EAW88322 EAW88323 P41222 AA621632 AI659247 AK075333 BAG52113 AK312817 BAG35674 AY026356 AAK07679 BC005939 AAH05939 BC041463 BG037037 BM686612 BT019921 AAV38724 BT019922 AAV38725 M61900 AAA36494 NM_000954 NP_000945
Function	Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. {ECO:0000269|PubMed:20667974, ECO:0000269|PubMed:9475419}.
Subcellular Location	Rough endoplasmic reticulum {ECO:0000269|PubMed:9065498}. Nucleus membrane {ECO:0000269|PubMed:9065498}. Golgi apparatus {ECO:0000269|PubMed:9065498}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:9065498}. Secreted {ECO:0000269|PubMed:9065498}. Note=Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted.
Tissue Specificity	Abundant in the brain and CNS, where it is expressed in tissues of the blood-brain barrier and secreted into the cerebro-spinal fluid. Abundantly expressed in the heart. In the male reproductive system, it is expressed in the testis, epididymis and prostate, and is secreted into the seminal fluid. Expressed in the eye and secreted into the aqueous humor. Lower levels detected in various tissue fluids such as serum, normal urine, ascitic fluid and tear fluid. Also found in a number of other organs including ovary, fimbriae of the fallopian tubes, kidney, leukocytes. {ECO:0000269|PubMed:10462696, ECO:0000269|PubMed:11882588, ECO:0000269|PubMed:7692978, ECO:0000269|PubMed:8599604, ECO:0000269|PubMed:8761996, ECO:0000269|PubMed:9065498, ECO:0000269|PubMed:9405674, ECO:0000269|PubMed:9475419, ECO:0000269|PubMed:9844724}.
Top Pathways	Arachidonic acid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Prostaglandin D Synthase (Lipocalin) full length protein - ab63850 from Abcam Category Protein Source E. coli Species Human

Human Prostaglandin D Synthase (Lipocalin) full length protein - ab105574 from Abcam Category Protein Source E. coli Species Human

Human Prostaglandin D Synthase (Lipocalin) full length protein - ab109669 from Abcam Category Protein Source Native Species Human

Human Prostaglandin D Synthase (Lipocalin) full length protein - ab125636 from Abcam Category Protein Source E. coli Species Human

Prostaglandin D Synthase (Lipocalin) peptide - ab188544 from Abcam Category Peptide

Prostaglandin D Synthase Antibody Blocking Peptide - LS-E27848 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PGD2 Synthase/PTGDS Blocking Peptide - NB110-59911PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

PGD2 Synthase/PTGDS Blocking Peptide - NB110-59909PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

PGD2 Synthase/PTGDS Recombinant Protein - H00005730-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human PGD2 Synthase/PTGDS Protein - NBP1-51078 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 50 µg, 250 µg Source E.coli Species Human

PTGDS Protein (OPPA01232) - OPPA01232 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Human PTGDS protein (His Tag) - orb139541 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Human Cells Species Human

Human PTGDS protein - orb169110 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

Human PTGDS protein - orb246419 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human Beta-Trace protein - orb81291 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E.coli

HPGDS protein (His tag) - 80R-2297 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

PGDS Blocking Peptide - 33R-2657 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PGDS Blocking Peptide - 33R-7239 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PTGDS Blocking Peptide - 33R-5773 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PTGDS protein (His tag) - 80R-1768 from Fitzgerald Category Protein Prices $255.00 Sizes 50 µg Source E.coli

PTGDS (23-190, His-tag) - AR09950PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 250 µg Source E. coli Species Human

PTGDS (23-190, His-tag) - AR09950PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 50 µg Source E. coli Species Human

PTGDS - H00005730-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PTGDS - H00005730-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Beta Trace, Human Recombinant - 228-10118-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

Search more