| Gene Symbol |
RNF123
|
| Entrez Gene |
63891
|
| Alt Symbol |
FP1477, KPC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger protein 123
|
| Other Description |
E3 ubiquitin-protein ligase RNF123|kip1 ubiquitination-promoting complex protein 1
|
| Swissprots |
Q71RH0 A1L4Q3 Q8IW18 Q5I022 Q9H0M8 Q5XPI4 Q9H5L8 Q9H9T2 Q6PFW4 A6NLS5
|
| Accessions |
Q5XPI4 AF370367 AAQ15203 AK022627 BAB14139 AK026968 BAB15607 AK090632 AK096353 BAG53271 AK126883 AK308130 AK308607 AL136729 CAB66663 AL832034 AL832138 AL832344 AM393062 CAL37940 AY744152 AAU93470 BC041145 AAH41145 BC057392 AAH57392 BC088801 AAH88801 BC112900 BC130632 AAI30633 CR627051 DA334003 XM_006713285 XP_006713348 XM_011533995 XP_011532297 XR_940486 NM_022064 NP_071347
|
| Function |
Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle. {ECO:0000269|PubMed:15531880, ECO:0000269|PubMed:16227581}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15531880}.
|