| Gene Symbol |
VNN2
|
| Entrez Gene |
8875
|
| Alt Symbol |
FOAP-4, GPI-80
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
vanin 2
|
| Other Description |
Vannin 2|glycosylphosphatidyl inositol-anchored protein GPI-80|pantetheinase|vanin-2|vascular non-inflammatory molecule 2
|
| Swissprots |
Q9UJF3 B2DFZ2 Q9UMW2 B2DFZ3 A8K7W0 A6NDY1 Q2XUN1 B2DFZ0 F6XL73 A0AUZ3 B2DFZ1 A8K4E3 O95498
|
| Accessions |
ABB72673 EAW48015 EAW48016 O95498 AB026705 BAB61019 AB435062 BAG30934 AB435063 BAG30935 AB435064 BAG30936 AB435065 BAG30937 AJ132100 CAA10569 AK290908 BAF83597 AK292125 BAF84814 AK298719 BAG60874 BC064641 BC126145 AAI26146 BC126147 AAI26148 BC144064 BM153251 D89974 BAA82525 DC412933 DC428640 DC428943 HQ258282 ADR83036 HQ258449 ADR83203 XM_006715593 XP_006715656 XM_011536231 XP_011534533 NM_078488 NP_511043 NM_001242350 NP_001229279 NM_004665 NP_004656 NR_034173 NR_034174 NR_110143 NR_110144 NR_110145 NR_110146
|
| Function |
Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil. {ECO:0000269|PubMed:11491533}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
|
| Tissue Specificity |
Widely expressed with higher expression in spleen and blood. {ECO:0000269|PubMed:19322213}.
|
| Top Pathways |
Pantothenate and CoA biosynthesis
|
