FAN1

Gene Symbol FAN1
Entrez Gene 22909
Alt Symbol KIAA1018, KMIN, MTMR15, hFAN1
Species Human
Gene Type protein-coding
Description FANCD2/FANCI-associated nuclease 1
Other Description coiled-coil domain-containing protein MTMR15|fanconi anemia associated nuclease 1|fanconi-associated nuclease 1|myotubularin-related protein 15
Swissprots Q9Y2M0 Q86WU8 A8K4M2
Accessions EAW61257 Q9Y2M0 AB023235 BAA76862 AK026787 AK290987 BAF83676 BC044890 BC047882 AAH47882 BP310263 BX647391 CR936727 CR936734 DA841207 EU832018 ACE86680 HG506830 HM560957 ADK11100 KJ534972 AHW56612 KJ534973 AHW56613 KJ535046 AHW56685 XM_005254232 XP_005254289 XM_005254234 XP_005254291 XM_005254235 XP_005254292 XM_005254236 XP_005254293 XM_006725538 XP_006725601 XM_006725539 XP_006725602 XM_006725540 XP_006725603 XM_006725541 XP_006725604 XM_011521370 XP_011519672 XM_011521371 XP_011519673 XM_011521372 XP_011519674 XM_011547388 XP_011545690 XM_011547389 XP_011545691 XM_011547390 XP_011545692 XM_011548898 XP_011547200 XM_011548899 XP_011547201 XM_011548900 XP_011547202 XM_011548901 XP_011547203 XM_011548902 XP_011547204 XM_011548903 XP_011547205 XM_011548904 XP_011547206 NM_001146094 NP_001139566 NM_001146095 NP_001139567 NM_001146096 NP_001139568 NM_014967 NP_055782
Function Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL- induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:206
Subcellular Location Nucleus {ECO:0000269|PubMed:20603015, ECO:0000269|PubMed:20603016, ECO:0000269|PubMed:20603073, ECO:0000269|PubMed:20671156, ECO:0000269|PubMed:20935496}. Note=Localizes at sites of DNA damage following recruitment by monoubiquitinated FANCD2 (PubMed:20603015, PubMed:20603016). Localizes to stalled replication forks via its UBZ-type zinc finger (PubMed:20935496). {ECO:0000269|PubMed:20603015, ECO:0000269|PubMed:20603016, ECO:0000269|PubMed:20935496}.
Top Pathways Fanconi anemia pathway

MTMR15 CRISPR/Cas9 KO Plasmid (h) - sc-411633 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTMR15 HDR Plasmid (h) - sc-411633-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTMR15 Double Nickase Plasmid (h) - sc-411633-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTMR15 Double Nickase Plasmid (h2) - sc-411633-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTMR15 CRISPR Activation Plasmid (h) - sc-411633-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTMR15 CRISPR Activation Plasmid (h2) - sc-411633-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTMR15 Lentiviral Activation Particles (h) - sc-411633-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTMR15 Lentiviral Activation Particles (h2) - sc-411633-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTMR15 siRNA (h) - sc-90145 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MTMR15 shRNA Plasmid (h) - sc-90145-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MTMR15 shRNA (h) Lentiviral Particles - sc-90145-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MTMR15 RNAi - H00022909-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU126471 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8470 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8470 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10250 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr10250

FAN1 siRNA (Human) - CRH7864 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FAN1 - MBS8227117 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FAN1 (NM_014967.4) - SHH292245 from Creative biogene

Category siRNA
Species Reactivities Human

Human FAN1 siRNA - orb268366 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FAN1 shRNA Plasmid (Human) - CHH7864 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FAN1 miRNA 3'UTR clone - MiUTR3H-12936 from Creative biogene

Species Reactivities Human

FAN1 miRNA 3'UTR clone - MiUTR3H-12937 from Creative biogene

Species Reactivities Human

FAN1 miRNA 3'UTR clone - MiUTR3H-12938 from Creative biogene

Species Reactivities Human

FAN1 miRNA 3'UTR clone - MiUTR3H-12939 from Creative biogene

Species Reactivities Human
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