ITPR1

Gene Symbol ITPR1
Entrez Gene 3708
Alt Symbol ACV, CLA4, INSP3R1, IP3R, IP3R1, PPP1R94, SCA15, SCA16, SCA29
Species Human
Gene Type protein-coding
Description inositol 1,4,5-trisphosphate receptor, type 1
Other Description IP3 receptor|IP3R 1|inositol 1,4,5-triphosphate receptor, type 1|inositol 1,4,5-trisphosphate receptor type 1|protein phosphatase 1, regulatory subunit 94|type 1 InsP3 receptor|type 1 inositol 1,4,5-trisphosphate receptor
Swissprots Q14643 Q14660 E9PDE9 Q99897 E7EPX7
Accessions EAW63908 EAW63909 EAW63910 EAW63911 EAW63912 EAW63913 EAW63914 EAW63915 Q14643 AB208868 BAD92105 AI470158 AK293752 BAG57174 AK294594 BAG57782 AK296235 BAG58955 AK309981 AK311008 AW501800 BC144563 AAI44564 BG202086 BM695661 BQ006717 CN431631 CV355426 D26070 BAA05065 DA060305 DB260851 DB544988 DB576768 L38019 AAB04947 S82269 AAD14386 U23850 XM_005265109 XP_005265166 XM_005265110 XP_005265167 XM_006713131 XP_006713194 XM_011533681 XP_011531983 XM_011533682 XP_011531984 XM_011533683 XP_011531985 XM_011533684 XP_011531986 XM_011533685 XP_011531987 XM_011533686 XP_011531988 XM_011533687 XP_011531989 XM_011533688 XP_011531990 XM_011533689 XP_011531991 XM_011533690 XP_011531992 XM_011533691 XP_011531993 XM_011533692 XP_011531994 NM_001099952 NP_001093422 NM_001168272 NP_001161744 NM_002222 NP_002213
Function Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). {ECO:0000250}.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue Specificity Widely expressed.
Top Pathways Inflammatory mediator regulation of TRP channels, Estrogen signaling pathway, Oxytocin signaling pathway, cGMP-PKG signaling pathway, Thyroid hormone synthesis

Phospho-IP3 Receptor (Ser1756) (D10E3) Rabbit mAb - 8548 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D10E3
Western blot analysis of extracts from mouse and rat brain using Phospho-IP3 Receptor (Ser1756) (D10E3) Rabbit mAb. The phospho-specificity of the antibody was verified by preincubating the antibody with no peptide, with IP3 receptor (Ser1756) phosphopeptide, or with IP3 receptor (Ser1756) non-phosphopeptide prior to incubating the membrane.

Phospho-IP3 Receptor (Ser1756) Antibody - 3760 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from mouse brain using Phospho-IP3 Receptor (Ser1756) Antibody. The phospho-specificity of the antibody was verified by preincubating the antibody with no peptide, with IP3 Receptor (Ser1756) phosphopeptide or with IP3 Receptor (Ser1756) non-phosphopeptide prior to incubating the membrane.

IP3 Receptor 1 (D53A5) Rabbit mAb - 8568 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D53A5
Western blot analysis of extracts from mouse and rat brain using IP3 Receptor 1 (D53A5) Rabbit mAb.

IP3 Receptor Antibody - 3763 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from mouse and rat brain using IP3 Receptor Antibody.

IP3R-I (C-20) - sc-6093 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IP3R-I (C-20): sc-6093. Western blot analysis of IP3R-I expression in HuT 78 whole cell lysate.

IP3R-I (E-8) - sc-271197 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IP3R-I (E-8): sc-271197. Western blot analysis of IP3R-I expression in HuT 78 whole cell lysate.

IP3R-I (E-20) - sc-26382 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IP3R-I (E-20): sc-26382. Western blot analysis of IP3R-I expression in HuT 78 whole cell lysate.

IP3R-I (H-80) - sc-28614 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IP3R-I (H-80): sc-28614. Western blot analysis of IP3R-I expression in HuT 78 whole cell lysate (A) and mouse brain tissue extract (B).

IP3R-I (V-20) - sc-26381 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-IP3 receptor (phospho S1598) antibody - ab111615 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111615 at 1/100 dilution staining ITPR1 in A549 cells by Immunofluorescence. The picture on the right is treated with the synthesized phosphopeptide.

Anti-IP3 receptor antibody - ab111087 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111087 at 1/50 dilution staining ITPR1 in paraffin-embedded Human Cervix carcinoma tissue by Immunohistochemistry. The image on the right is treated with the synthesized peptide.

Anti-IP3 receptor antibody - ab97823 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IP3 receptor antibody (ab97823) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : PC3 (Human prostate carcinoma cell line) Whole Cell Lysate Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-IP3 receptor antibody - ab118524 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Brain, Cerebellum (formalin-fixed, paraffin-embedded) stained with ab118524 at 10 µg/ml followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-IP3 receptor antibody [EPR4536] - ab125076 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4536
All lanes : Anti-IP3 receptor antibody [EPR4536] (ab125076) at 1/1000 dilutionLane 1 : SH-SY5Y cell lysateLane 2 : HeLa cell lysateLane 3 : HuT78 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-IP3 receptor antibody [EPR4537] - ab108517 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4537
All lanes : Anti-IP3 receptor antibody [EPR4537] (ab108517) at 1/1000 dilutionLane 1 : Rat brain lysateLane 2 : SH-SY5Y lysateLane 3 : Mouse brain lysateLane 4 : HeLa brain lysateLysates/proteins at 10 µg per lane.

Anti-IP3 receptor antibody [S24-18] - C-terminal - ab190239 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone S24-18
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain, cerebellum (Purkinje) tissue labeling IP3 receptor with ab190239 at 10 µg/ml.

Anti-ITPR1 / IP3 Receptor Type 1 Antibody (phospho-Ser1756) - LS-C71063 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ITPR1 / IP3 Receptor Type 1 Antibody (Met2750) - LS-C71062 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ITPR1 / IP3 Receptor Type 1 Antibody (clone 2B6) - LS-C197563 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2B6

Anti-IP3R1 / IP3R Antibody (aa2680-2749, clone S24-18, Atto 655) - LS-C228495 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone S24-18

Anti-IP3R1 / IP3R Antibody (aa2680-2749, clone S24-18, Atto 680) - LS-C228496 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone S24-18

Anti-IP3R1 / IP3R Antibody (aa2680-2749, clone S24-18, Atto 700) - LS-C228497 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone S24-18

Anti-IP3R1 / IP3R Antibody (aa2680-2749, clone S24-18, AP) - LS-C228498 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone S24-18

Anti-IP3R1 / IP3R Antibody (aa2680-2749, clone S24-18, APC) - LS-C228499 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone S24-18

Anti-ITPR1 / IP3 Receptor Type 1 Antibody (Internal, clone EPR4537) - LS-C138557 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4537
Western blot analysis on (A) rat brain, (B) SH-SY5Y, (C) mouse brain, and (D) HeLa lysates using anti-ITPR1 antibody.
Search more