FZD6

Gene Symbol FZD6
Entrez Gene 8323
Alt Symbol FZ-6, FZ6, HFZ6, NDNC10
Species Human
Gene Type protein-coding
Description frizzled class receptor 6
Other Description frizzled 6, seven transmembrane spanning receptor|frizzled family receptor 6|frizzled homolog 6|frizzled-6|seven transmembrane helix receptor
Swissprots Q6P9C3 B4DRN0 O60353 Q8WXR9 Q6N0A5
Accessions AAL50384 BAB89325 BAC05925 CAH05464 EAW91867 EAW91868 EAW91869 EAW91870 EAW91871 EAW91872 EAW91873 O60353 AB012911 BAA25686 AB209734 BAD92971 AF072873 AAD41637 AK296824 BAG59395 AK299341 BAG61342 AK304092 BAG64998 AK313789 BAG36526 AK316544 BAH14915 AU130184 AU152862 AW511572 BC036106 BC060836 AAH60836 BX640609 CAE45715 CD652975 DC417200 DC418286 XR_428385 NM_001164615 NP_001158087 NM_001164616 NP_001158088 NM_003506 NP_003497
Function Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical face
Subcellular Location Membrane {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein {ECO:0000255}. Cell surface {ECO:0000250|UniProtKB:Q61089}. Apical cell membrane; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with FZD3 at the apical face of cells (By similarity). {ECO:0000250|UniProtKB:Q61089}.
Tissue Specificity Detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and kidney.
Top Pathways Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway

Frizzled6 (D16E5) Rabbit mAb - 5158 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D16E5
Western blot analysis of extracts from 786-0, HeLa, and HCT 116 cells using Frizzled6 (D16E5) Rabbit mAb.

frizzled-6 (C-12) - sc-393791 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
frizzled-6 (C-12): sc-393791. Western blot analysis of frizzled-6 expression in Jurkat whole cell lysate.

frizzled-6 (E-19) - sc-32148 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
frizzled-6 (E-19): sc-32148. Western blot analysis of frizzled-6 expression in rat skeletal muscle tissue extract.

frizzled-6 (C-20) - sc-32150 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
frizzled-6 (C-20): sc-32150. Western blot analysis of frizzled-6 expression in non-transfected: sc-117752 (A) and mouse frizzled-6 transfected: sc-120321 (B) 293T whole cell lysates.

frizzled-6 (H-100) - sc-366604 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

frizzled-6 (D-2) - sc-393113 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
frizzled-6 (D-2): sc-393113. Western blot analysis of frizzled-6 expression in HeLa whole cell lysate.

frizzled-6 (M-19) - sc-32152 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
frizzled-6 (M-19): sc-32152. Western blot analysis of frizzled-6 expression in non-transfected: sc-117752 (A) and mouse frizzled-6 transfected: sc-120321 (B) 293T whole cell lysates.

Anti-Frizzled 6 antibody - ab105192 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab105192 at 0.4 µg/ml staining Frizzled 6 in HeLa whole cell lysate immunoprecipitated using ab105192 at 3 µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence. Exposure time: 3 seconds

Anti-Frizzled 6 antibody [EPR7279] - ab128916 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7279
All lanes : Anti-Frizzled 6 antibody [EPR7279] (ab128916) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : HT 29 cell lysateLane 3 : 293T cell lysateLane 4 : Jurkat cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-Frizzled 6 antibody - N-terminal - ab200465 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-Frizzled 6 antibody - N-terminal (ab200465) at 1/500 dilution + Mouse thymus total cell extracts

Anti-FZD6 / Frizzled 6 Antibody - LS-C6911 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-FZD6 / Frizzled 6 Antibody - LS-C6912 from LifeSpan Bioscience

Prices $575.00
Sizes 500 µg
Host Rat
Clonality Monoclonal

Anti-FZD6 / Frizzled 6 Antibody (Biotin) - LS-C6913 from LifeSpan Bioscience

Prices $650.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-FZD6 / Frizzled 6 Antibody (aa121-170) - LS-C120597 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of COS7 cells, using FZD6 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-FZD6 / Frizzled 6 Antibody (Internal, clone EPR7279) - LS-C152425 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7279
Western blot analysis on (A) HeLa, (B) HT-29, (C) 293T, and (D) Jurkat cell lysates using anti-Frizzled-6 antibody.

Anti-FZD6 / Frizzled 6 Antibody (aa493-520, AP) - LS-C214429 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FZD6 / Frizzled 6 Antibody (aa539-588) - LS-C110621 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FZD6 / Frizzled 6 antibody LS-C110621 Western blot of ACHN lysate.

Anti-FZD6 / Frizzled 6 Antibody (aa493-520, APC) - LS-C214430 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FZD6 / Frizzled 6 Antibody (aa493-520, Azide-free, HRP) - LS-C214432 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FZD6 / Frizzled 6 Antibody (aa493-520, Biotin) - LS-C214431 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FZD6 / Frizzled 6 Antibody (aa493-520, FITC) - LS-C214433 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FZD6 / Frizzled 6 Antibody (aa493-520, PE) - LS-C214434 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FZD6 / Frizzled 6 Antibody (aa656-706) - LS-C289669 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FZD6 / Frizzled 6 Antibody (aa500-550) - LS-C289666 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FZD6 / Frizzled 6 Antibody (N-Terminus) IHC-plus™ - LS-A4481 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Frizzled 6 / FZD6 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-A4481 dilution 14 ug/ml.
Search more