| Gene Symbol |
DNAJC7
|
| Entrez Gene |
7266
|
| Alt Symbol |
DJ11, DJC7, TPR2, TTC2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DnaJ (Hsp40) homolog, subfamily C, member 7
|
| Other Description |
TPR repeat protein 2|dnaJ homolog subfamily C member 7|tetratricopeptide repeat domain 2|tetratricopeptide repeat protein 2
|
| Swissprots |
Q7Z784 Q99615
|
| Accessions |
EAW60788 EAW60789 Q99615 AB209834 BAD93071 AK291047 BAF83736 AK296602 BAG59215 AK298860 BAG60982 AK308016 AK316081 BAH14452 AM393511 CAL38388 BC003601 AAH03601 BC011837 AAH11837 BC033772 AAH33772 BP378441 BQ445927 BX647209 DB453150 DQ893064 ABM83990 DQ896317 ABM87316 U46571 AAB36872 XM_011525166 XP_011523468 XM_011525167 XP_011523469 XM_011525168 XP_011523470 XM_011525169 XP_011523471 XM_011525170 XP_011523472 XR_934540 NM_001144766 NP_001138238 NM_003315 NP_003306 NR_029431
|
| Function |
Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone- substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Note=Colocalizes with NR1I3 to microtubules. {ECO:0000250}.
|
![Western Blot: DNAJC7 Overexpression Lysate (Adult Normal) [NBL1-09956] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DNAJC7.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3380_DNAJC7%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09956-img0002.jpg)