| Gene Symbol |
Rpl13a
|
| Entrez Gene |
22121
|
| Alt Symbol |
1810026N22Rik, Tstap198-7, tum-antigen
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
ribosomal protein L13A
|
| Other Description |
60S ribosomal protein L13a|tissue specific transplantation antigen P198-7|transplantation antigen P198|tum-P198 antigen|tum-transplantation antigen P198
|
| Swissprots |
P19253
|
| Accessions |
CAA35908 EDL22806 P19253 AK007609 BAB25132 AK077512 AK146318 BAE27073 AK156035 BAE33555 AK159882 AK168784 BAE40618 AK168903 BAE40717 AK170030 BAE41520 AK189288 AK213140 AV445288 BC034450 BC042392 BC065799 BC082289 AAH82289 BC086896 AAH86896 CT010169 CAJ18377 NM_009438 NP_033464
|
| Function |
Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma- induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop- containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. {ECO:0000250, ECO:0000269|PubMed:23071094}.
|
| Top Pathways |
Ribosome
|