| Gene Symbol | NEU1 |
|---|---|
| Entrez Gene | 4758 |
| Alt Symbol | NANH, NEU, SIAL1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | sialidase 1 (lysosomal sialidase) |
| Other Description | G9 sialidase|N-acetyl-alpha-neuraminidase 1|acetylneuraminyl hydrolase|exo-alpha-sialidase|lysosomal sialidase|sialidase-1 |
| Swissprots | Q99519 |
| Accessions | AAD21814 AAT11275 AAT11276 AAT11277 BAB63297 EAX03536 EAX03537 Q99519 AB209011 BAD92248 AF040958 AAB96774 AK290966 BAF83655 AK313006 BAG35842 BC000722 AAH00722 BC011900 AAH11900 BT007206 AAP35870 CA428930 CR456717 CAG32998 CR541916 CAG46714 DB122914 DQ890716 ABM81642 DQ892186 ABM83112 DQ893896 ABM84822 DQ895380 ABM86306 U84246 AAD09239 X78687 CAA55356 NM_000434 NP_000425 |
| Function | Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. {ECO:0000269|PubMed:8985184}. |
| Subcellular Location | Lysosome membrane; Peripheral membrane protein; Lumenal side. Lysosome lumen. Cell membrane. Cytoplasmic vesicle. Note=Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles. |
| Tissue Specificity | Highly expressed in pancreas, followed by skeletal muscle, kidney, placenta, heart, lung and liver. Weakly expressed in brain. {ECO:0000269|PubMed:8985184, ECO:0000269|PubMed:9054950}. |
| Top Pathways | Lysosome, Sphingolipid metabolism, Other glycan degradation |