ST5

Gene Symbol ST5
Entrez Gene 6764
Alt Symbol DENND2B, HTS1, p126
Species Human
Gene Type protein-coding
Description suppression of tumorigenicity 5
Other Description DENN/MADD domain containing 2B|heLa tumor suppression 1|suppression of tumorigenicity 5 protein
Swissprots Q8NE12 Q7KZ12 Q9BQQ6 Q16492 P78524 P78523 B2R6X7 Q7KYY2 B3KXQ6
Accessions AAN86355 CAC35387 EAW68617 EAW68618 P78524 AK126554 BAC86590 AK127763 BAG54568 AK293245 BAG56779 AK302824 BAG64021 AK307617 AK309929 AK312305 AK312758 BAG35624 BC036655 AAH36655 BX647431 BX647474 DQ892483 ABM83409 DQ895694 ABM86620 S45936 AAB23647 U15131 AAC50925 U15779 AAB97097 U15780 AAC50926 XM_005253077 XP_005253134 XM_005253083 XP_005253140 XM_011520309 XP_011518611 XM_011520310 XP_011518612 XM_011520311 XP_011518613 XM_011520312 XP_011518614 XM_011520313 XP_011518615 XM_011520314 XP_011518616 XM_011520315 XP_011518617 XM_011520316 XP_011518618 XM_011520317 XP_011518619 XM_011520318 XP_011518620 XM_011520319 XP_011518621 XM_011520320 XP_011518622 XM_011520321 XP_011518623 XM_011520322 XP_011518624 XM_011520323 XP_011518625 XM_011520324 XP_011518626 XM_011520325 XP_011518627 XM_011520326 XP_011518628 XM_011520327 XP_011518629 XM_011520328 XP_011518630 XM_011520329 XP_011518631 XM_011520330 XP_011518632 XR_930887 XR_930888 XR_930889 NM_005418 NP_005409 NM_139157 NP_631896 NM_213618 NP_998783
Function Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth. {ECO:0000269|PubMed:10229203, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:9632734}.
Tissue Specificity Widely expressed with the exception of peripheral blood lymphocytes. Isoform 1 is expressed in several epithelial and fibroblast (including tumorigenic) but absent in lymphoid cell lines (at protein level). Isoform 3 is expressed in primary cell or weakly tumorigenic but not in tumorigenic cell lines (at protein level). {ECO:0000269|PubMed:10229203}.

ST5 (S-19) - sc-244229 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-ST5 antibody - ab64897 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
This image shows formalin fixed, paraffin embedded human spleen tissue stained with ab64897 at 5µg/ml.

Anti-ST5 antibody - ab187759 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ST5 antibody - ab138294 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ST5 antibody (ab138294) at 1/500 dilution + COLO205 cell lysate at 30 µg

Anti-ST5 antibody - ab111556 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HTS1 / ST5 Antibody (aa1108-1137, AP) - LS-C224159 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTS1 / ST5 Antibody (clone 1A3) - LS-C198271 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1A3

Anti-HTS1 / ST5 Antibody (aa1108-1137, APC) - LS-C224160 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTS1 / ST5 Antibody (aa1108-1137, Biotin) - LS-C224161 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTS1 / ST5 Antibody (aa1108-1137, FITC) - LS-C224162 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTS1 / ST5 Antibody (aa1108-1137, Azide-free, HRP) - LS-C224163 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTS1 / ST5 Antibody (aa1108-1137, PE) - LS-C224164 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTS1 / ST5 Antibody (aa930-1137) - LS-C311525 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HTS1 / ST5 Antibody (aa1108-1137) - LS-C330179 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTS1 / ST5 Antibody (aa387-436) - LS-C135786 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ST5 antibody LS-C135786 Western blot of 721_B Cell lysate. Antibody concentration 1 ug/ml.

Anti-HTS1 / ST5 Antibody (aa388-437) - LS-C200728 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from COLO205 cells using ST5 antibody.

Anti-HTS1 / ST5 Antibody (aa411-460) - LS-C118967 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from COLO205 cells, using ST5 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-HTS1 / ST5 Antibody (aa571-586) - LS-C313379 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
WB of HTS1 / ST5 antibody. All lanes: Anti-ST5 at 0.5ug/ml. Lane 1: Rat Testis Tissue Lysate at 40ug. Lane 2: A431 Whole Cell Lysate at 40ug. Lane 3: HELA Whole Cell Lysate at 40ug. Lane 4: COLO320 Whole Cell Lysate at 40ug. Lane 5: NIH Whole Cell Lysate at 40ug. Predicted bind size: 126KD. Observed bind size: 126KD.

Anti-HTS1 / ST5 Antibody (aa1121-1137) IHC-plus™ - LS-B905 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ST5 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B905 concentration 5 ug/ml.

ST5 Antibody - NBP2-13391 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: ST5 Antibody [NBP2-13391] - Staining of human cell line U-2 OS shows positivity in nucleus but excluded from the nucleoli.

ST5 Antibody - H00006764-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

ST5 Antibody (1A3) - H00006764-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1A3

ST5 Polyclonal Antibody - bs-6112R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ST5 antibody produced in rabbit - HPA046796 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-ST5:<B>Cat. No. HPA046796</B>: Immunohistochemical staining of human cerebral cortex shows strong nuclear positivity in neuronal cells.

Anti-ST5 antibody produced in rabbit - SAB4502865 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-ST5, N-Terminal: <B>Cat. No. SAB4502865</B>: Immunoblotting analysis of extracts from COLO205 cells, using Anti-ST5, N-Terminal antibody. The lane on the left was treated with the Anti-ST5, N-Terminal antibody. The lane on the right (negative control) was treated with both Anti-ST5, N-Terminal antibody and the synthesized immunogen peptide.
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