Gene Symbol | IFNG |
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Entrez Gene | 3458 |
Alt Symbol | IFG, IFI |
Species | Human |
Gene Type | protein-coding |
Description | interferon, gamma |
Other Description | IFN-gamma|immune interferon|interferon gamma |
Swissprots | Q53ZV4 B5BU88 P01579 |
Accessions | AAB59534 AAK53058 CAQ43129 EAW97180 P01579 AB451324 BAG70138 AB451453 BAG70267 AF506749 AAM28885 AM903379 CAP17327 AY044154 AAK95388 AY255837 AAP20098 AY255839 AAP20100 BC070256 AAH70256 EF173872 ABM53145 V00543 CAA23804 X01992 CAA26022 X13274 CAA31639 X62468 CAA44325 X62469 CAA44326 X62470 CAA44327 X62471 CAA44328 X62472 CAA44329 X62473 CAA44330 X62474 CAA44331 X87308 NM_000619 NP_000610 |
Function | Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. |
Subcellular Location | Secreted. |
Tissue Specificity | Released primarily from activated T lymphocytes. |
Top Pathways | Proteasome, Epstein-Barr virus infection, African trypanosomiasis, Herpes simplex infection, Tuberculosis |
IFN-γ CRISPR/Cas9 KO Plasmid (h) - sc-418061 from Santa Cruz Biotechnology
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IFN-γ HDR Plasmid (h) - sc-418061-HDR from Santa Cruz Biotechnology
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IFN-γ Double Nickase Plasmid (h) - sc-418061-NIC from Santa Cruz Biotechnology
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IFN-γ Double Nickase Plasmid (h2) - sc-418061-NIC-2 from Santa Cruz Biotechnology
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IFN-γ CRISPR Activation Plasmid (h) - sc-418061-ACT from Santa Cruz Biotechnology
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IFN-γ CRISPR Activation Plasmid (h2) - sc-418061-ACT-2 from Santa Cruz Biotechnology
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IFN-γ Lentiviral Activation Particles (h) - sc-418061-LAC from Santa Cruz Biotechnology
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IFN-γ Lentiviral Activation Particles (h2) - sc-418061-LAC-2 from Santa Cruz Biotechnology
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IFN-γ siRNA (h) - sc-39606 from Santa Cruz Biotechnology
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IFN-γ shRNA Plasmid (h) - sc-39606-SH from Santa Cruz Biotechnology
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IFN-γ shRNA (h) Lentiviral Particles - sc-39606-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU028351 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1764 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1764 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05467 from Sigma-Aldrich
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IFNG siRNA (Human) - CRH2344 from Cohesion Biosciences
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IFNG - MBS8218166 from MyBioSource
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shRNA set against Human IFNG (NM_000619.2) - SHH317165 from Creative biogene
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shRNA set against Human IFNG(NM_000619.2) - SHL167032 from Creative biogene
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Human IFNG siRNA - orb262846 from Biorbyt
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IFNG shRNA Plasmid (Human) - CHH2344 from Cohesion Biosciences
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IFNG miRNA 3'UTR clone - MiUTR1H-04817 from Creative biogene
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