Gene Symbol | FTH1 |
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Entrez Gene | 2495 |
Alt Symbol | FHC, FTH, FTHL6, HFE5, PIG15, PLIF |
Species | Human |
Gene Type | protein-coding |
Description | ferritin, heavy polypeptide 1 |
Other Description | apoferritin|cell proliferation-inducing gene 15 protein|ferritin H subunit|ferritin heavy chain|placenta immunoregulatory factor|proliferation-inducing protein 15 |
Swissprots | Q3SWW1 P02794 B3KNR5 Q3KRA8 |
Accessions | AAA52438 ABF47097 CAA27205 CAP19952 EAW73989 EAW73990 EAW73991 EAW73992 EAW73993 EAW73994 EAW73995 EAW73996 EAW73997 EAW73998 EAW73999 EAW74000 EAW74001 P02794 AB062402 BAB93489 AF088851 AAF89523 AK311818 AY258285 AAP82230 BC000857 AAH00857 BC001399 AAH01399 BC011359 AAH11359 BC013724 AAH13724 BC015156 AAH15156 BC015946 BC016009 AAH16009 BC016857 AAH16857 BC020300 BC035441 BC063514 AAH63514 BC066341 AAH66341 BC066961 AAH66961 BC070494 AAH70494 BC073750 AAH73750 BC104643 AAI04644 BC105802 AAI05803 BM971420 BQ887222 D28463 BAA05829 DQ891113 ABM82039 DQ894293 ABM85219 L20941 AAA35833 M11146 AAA52437 M12937 AAA35830 M15383 AAA52479 M97164 AAA35832 X00318 CAA25086 NM_002032 NP_002023 |
Function | Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). {ECO:0000250}. |
Tissue Specificity | Expressed in the liver. {ECO:0000269|PubMed:11389486}. |
Top Pathways | Mineral absorption |
ferritin heavy chain CRISPR/Cas9 KO Plasmid (h) - sc-418152 from Santa Cruz Biotechnology
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ferritin heavy chain HDR Plasmid (h) - sc-418152-HDR from Santa Cruz Biotechnology
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ferritin heavy chain Double Nickase Plasmid (h) - sc-418152-NIC from Santa Cruz Biotechnology
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ferritin heavy chain Double Nickase Plasmid (h2) - sc-418152-NIC-2 from Santa Cruz Biotechnology
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ferritin heavy chain CRISPR Activation Plasmid (h) - sc-418152-ACT from Santa Cruz Biotechnology
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ferritin heavy chain CRISPR Activation Plasmid (h2) - sc-418152-ACT-2 from Santa Cruz Biotechnology
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ferritin heavy chain Lentiviral Activation Particles (h) - sc-418152-LAC from Santa Cruz Biotechnology
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ferritin heavy chain Lentiviral Activation Particles (h2) - sc-418152-LAC-2 from Santa Cruz Biotechnology
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ferritin heavy chain siRNA (h) - sc-40575 from Santa Cruz Biotechnology
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ferritin heavy chain shRNA Plasmid (h) - sc-40575-SH from Santa Cruz Biotechnology
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ferritin heavy chain shRNA (h) Lentiviral Particles - sc-40575-V from Santa Cruz Biotechnology
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Ferritin RNAi - H00002495-R01 from Novus Biologicals
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MISSION® esiRNA - EHU114171 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8976 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8976 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04341 from Sigma-Aldrich
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FTH1 siRNA (Human) - CRH1660 from Cohesion Biosciences
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FTH1 - MBS8233041 from MyBioSource
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shRNA set against Human FTH1(NM_002032.2) - SHH069509 from Creative biogene
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Human FTH1 siRNA - orb262162 from Biorbyt
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FTH1 shRNA Plasmid (Human) - CHH1660 from Cohesion Biosciences
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FTH1 miRNA 3'UTR clone - MiUTR1H-03866 from Creative biogene
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