| Gene Symbol |
PTGER3
|
| Entrez Gene |
5733
|
| Alt Symbol |
EP3, EP3-I, EP3-II, EP3-III, EP3-IV, EP3e, PGE2-R
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
prostaglandin E receptor 3 (subtype EP3)
|
| Other Description |
PGE receptor, EP3 subtype|PGE2 receptor EP3 subtype|prostaglandin E receotor EP3 subtype 3 isoform|prostaglandin E2 receptor EP3 subtype|prostaglandin receptor (PGE-2)|prostanoid EP3 receptor
|
| Swissprots |
Q5CZ63 Q12944 Q5CZ59 Q12943 B0AZN4 Q16546 O00326 B1AK19 Q5CZ64 P43115 B5BUP5 Q5CZ62 Q5CZ61 Q12945
|
| Accessions |
BAA19949 BAA19950 BAA19951 BAA19952 BAA19954 BAA19955 BAA19956 BAA19957 CAE83503 CAE83507 CAE83508 CAJ33690 CCF77027 CCF77028 CCF77029 CCF77030 CCF77031 CCF77032 CCF77033 CCF77034 CCF77035 CCF77036 EAX06436 EAX06437 EAX06438 EAX06439 EAX06440 EAX06441 EAX06442 EAX06443 EAX06444 EAX06445 EAX06446 P43115 AB451481 BAG70295 AI273491 AK290634 BAF83323 AK315825 BAF98716 AL050227 AL700981 AY387856 AAQ90021 AY429108 AAR07903 BC024229 AAH24229 BC118578 AAI18579 BC118659 AAI18660 D38297 BAA07416 D38298 BAA07417 D38299 BAA07418 D38300 BAA07419 D38301 BAA07420 D86097 BAA19958 D86098 BAA19959 EF534325 ABS57464 HG492164 HQ447638 ADQ32123 L26976 AAA60076 L27488 AAC13372 L27489 AAC13373 L27490 AAC13374 L32660 AAA68191 L32661 AAA68192 L32662 AAA68193 S68874 AAB29855 S68875 AAD14026 S69200 AAB29854 S69326 AAB30208 U13214 AAA21130 U13215 AAA21131 U13216 AAA21132 U13217 AAA21133 U13218 AAA21134 X83857 CAA58737 X83858 CAA58738 X83859 CAA58739 X83860 CAA58740 X83861 CAA58741 X83862 CAA58742 X83863 CAA58743 XM_011541809 XP_011540111 XM_011541810 XP_011540112 XM_011541811 XP_011540113 XR_946714 NM_001126044 NP_001119516 NM_198714 NP_942007 NM_198715 NP_942008 NM_198716 NP_942009 NM_198717 NP_942010 NM_198718 NP_942011 NM_198719 NP_942012 NR_028292 NR_028293 NR_028294 NM_000957 NM_198712 NM_198713 NM_198720
|
| Function |
Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels. {ECO:0000269|PubMed:18023986}.
|
| Top Pathways |
Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction
|