AOX1

Gene Symbol	AOX1
Entrez Gene	316
Alt Symbol	AO, AOH1
Species	Human
Gene Type	protein-coding
Description	aldehyde oxidase 1
Other Description	aldehyde oxidase|azaheterocycle hydroxylase
Swissprots	Q06278 O14765 Q9BYF0 Q53RR8 Q9UPG6 Q53TV3
Accessions	AAB83966 AAB83968 AAX93285 AAY24265 CAW36666 CAW39000 CAW41181 CAW47197 CAW63617 CAW71847 CAW80339 CAW82831 CAW86206 CAY77140 CBC02619 CBC04872 CBC06832 CBC12951 CBC45781 CBC62201 CBC79136 CBC84084 CBC89038 EAW70208 EAW70209 Q06278 AB046692 BAB40305 AK297930 BAG60247 AK301052 BAG62663 AK307738 AL079797 BC117179 AAI17180 BC117181 AAI17182 BM681054 CB153864 L11005 AAA96650 XM_011511062 XP_011509364 XR_922913 NM_001159 NP_001150
Function	Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and N- methylphthalazinium, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis. {ECO:0000269|PubMed:20444863, ECO:0000269|PubMed:22031625, ECO:0000269|PubMed:22279051, ECO:0000269|PubMed:22522748, ECO:0000269|PubMed:22996261, ECO:0000269|PubMed:2
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:18671973, ECO:0000269|PubMed:20444863, ECO:0000269|PubMed:23857892}.
Tissue Specificity	Abundant in liver, expressed in adipose tissue and at lower levels in lung, skeletal muscle, pancreas. In contrast to mice, no significant gender difference in AOX1 expression level (at protein level). {ECO:0000269|PubMed:18066686, ECO:0000269|PubMed:18671973, ECO:0000269|PubMed:20444863, ECO:0000269|PubMed:22031625, ECO:0000269|PubMed:22522748, ECO:0000269|PubMed:23857892, ECO:0000269|PubMed:8248161}.
Top Pathways	Tyrosine metabolism, Vitamin B6 metabolism, Nicotinate and nicotinamide metabolism, Retinol metabolism, Tryptophan metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

AOX1 (D-8) - sc-365291 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

AOX1 (H-64) - sc-98500 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

AOX1 (S-12) - sc-109498 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

AOX1 (T-15) - sc-109499 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Aldehyde Oxidase antibody - ab92519 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Aldehyde Oxidase antibody - ab91152 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-Aldehyde Oxidase antibody - C-terminal - ab197828 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-AOX1 / Aldehyde Oxidase Antibody (Internal, AP) - LS-C274843 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-AOX1 / Aldehyde Oxidase Antibody (Internal, Biotin) - LS-C274845 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-AOX1 / Aldehyde Oxidase Antibody (Internal, APC) - LS-C274844 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-AOX1 / Aldehyde Oxidase Antibody (Internal, Azide-free, HRP) - LS-C274848 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-AOX1 / Aldehyde Oxidase Antibody (Internal, FITC) - LS-C274847 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-AOX1 / Aldehyde Oxidase Antibody (Internal, PE) - LS-C274849 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-AOX1 / Aldehyde Oxidase Antibody (aa521-570) - LS-C119708 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-AOX1 / Aldehyde Oxidase Antibody (FITC) - LS-C317227 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-AOX1 / Aldehyde Oxidase Antibody - LS-C313668 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-AOX1 / Aldehyde Oxidase Antibody (aa698-726) - LS-C156378 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-AOX1 / Aldehyde Oxidase Antibody (Internal) - LS-C326778 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-AOX1 / Aldehyde Oxidase Antibody (HRP) - LS-C317228 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-AOX1 / Aldehyde Oxidase Antibody - LS-C332667 from LifeSpan Bioscience Prices $305.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-AOX1 / Aldehyde Oxidase Antibody (Biotin) - LS-C317224 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-AOX1 / Aldehyde Oxidase Antibody IHC-plus™ - LS-B12274 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Aldehyde Oxidase 1/AOX1 Antibody [Unconjugated] - AF5928 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Goat Clonality Polyclonal

Aldehyde Oxidase 1/AOX1 Antibody - NBP1-89070 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Aldehyde Oxidase 1/AOX1 Antibody - NBP1-89071 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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