| Gene Symbol |
INTS3
|
| Entrez Gene |
65123
|
| Alt Symbol |
C1orf193, C1orf60, INT3, SOSS-A, SOSSA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
integrator complex subunit 3
|
| Other Description |
SOSS complex subunit A|sensor of single-strand DNA complex subunit A|sensor of ssDNA A|sensor of ssDNA subunit A
|
| Swissprots |
Q68E01 Q6AI57 Q9H6S9 Q5VUR0 Q69YR5 Q68DJ1 A8K1W0 D3DV57 Q8NC46 Q4G0E5 B4DQC8 Q5VUQ5 Q6DKG7 Q5VUQ6 Q8TB23 B4E3U9 Q5VUR1 Q6MZQ4 Q6MZZ9
|
| Accessions |
DAA05722 EAW53279 EAW53280 EAW53281 EAW53282 EAW53283 Q68E01 AF130066 AAG35494 AK025572 BAB15174 AK055174 AK074979 BAC11329 AK091908 AK094402 AK126799 AK225294 AK290025 BAF82714 AK298746 BAG60890 AK304874 BAG65611 AL080172 AL832133 CAH10398 BC025254 AAH25254 BC054513 AAH54513 BC073985 AAH73985 BC098431 AAH98431 BC105092 AAI05093 BC105094 AAI05095 BC116458 AAI16459 BX640786 CAE45876 BX640950 CAE45974 CR627233 CAH10366 CR749212 CAH18069 CR749376 CAH18229 XM_005245459 XP_005245516 XM_005245461 XP_005245518 XM_005276735 XP_005276792 XM_005276737 XP_005276794 XM_006711490 XP_006711553 XM_006711491 XP_006711554 XM_006726204 XP_006726267 XM_006726205 XP_006726268 XM_011509906 XP_011508208 XM_011509907 XP_011508209 XM_011546922 XP_011545224 XM_011546923 XP_011545225 NM_023015 NP_075391
|
| Function |
Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}. Note=Localizes to nuclear foci following DNA damage.
|
