| Gene Symbol | MXI1 |
|---|---|
| Entrez Gene | 4601 |
| Alt Symbol | MAD2, MXD2, MXI, bHLHc11 |
| Species | Human |
| Gene Type | protein-coding |
| Description | MAX interactor 1, dimerization protein |
| Other Description | MAX dimerization protein 2|Max-related transcription factor|class C basic helix-loop-helix protein 11|max-interacting protein 1 |
| Swissprots | P50539 Q96E53 Q15887 B1ANN7 Q6FHW2 D3DR25 D3DRA9 |
| Accessions | AAC50446 AAD14282 AAT84074 EAW49565 EAW49566 EAW49567 EAW49568 EAW49569 EAW49570 P50539 AA640393 AA854855 AI373426 AI580132 AK303949 BAG64876 AK307090 AK309718 AL538051 AW291670 BC012907 AAH12907 BC016678 BC035128 AAH35128 BF056857 BG700036 BM668806 BM927870 BQ924073 BT007069 AAP35732 BX417051 CB960506 CF594363 CR536576 CAG38813 D63940 BAA09972 DQ891664 ABM82590 DQ894851 ABM85777 NM_001008541 NP_001008541 NM_005962 NP_005953 NM_130439 NP_569157 |
| Function | Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX. |
| Subcellular Location | Nucleus. |
| Tissue Specificity | High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle. |