| Gene Symbol | Syvn1 |
|---|---|
| Entrez Gene | 74126 |
| Alt Symbol | 1200010C09Rik, AW211966, C85322, D530017H19Rik, Hrd1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | synovial apoptosis inhibitor 1, synoviolin |
| Other Description | E3 ubiquitin-protein ligase synoviolin|synoviolin 1 |
| Swissprots | Q9DBY1 Q8CGB5 Q80T88 |
| Accessions | EDL33194 EDL33195 EDL33196 Q9DBY1 AK004688 BAB23474 AK122558 BAC65840 AK143720 AK172097 AK190544 AK193174 AK194583 AK200543 BB676375 BC032931 BC042199 AAH42199 BC046829 AAH46829 BC057917 AAH57917 BC080722 AAH80722 CD349490 XM_006531850 XP_006531913 NM_001164709 NP_001158181 NM_028769 NP_083045 |
| Function | Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. Required for embryogenesis. {ECO:0000269|PubMed:12975321, ECO:0000269|PubMed:15611074, ECO:0000269|PubMed:17170702}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:17059562}; Multi-pass membrane protein {ECO:0000269|PubMed:17059562}. |
| Tissue Specificity | Ubiquitously expressed, with highest levels in bone, spleen, lung and testis. In the brain, present in neurons but not in glial cells. Up-regulated in synovial tissues from mice with collagen-induced arthritis (at protein level). {ECO:0000269|PubMed:12975321, ECO:0000269|PubMed:17059562}. |
| Top Pathways | Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum |