Syvn1

Gene Symbol Syvn1
Entrez Gene 74126
Alt Symbol 1200010C09Rik, AW211966, C85322, D530017H19Rik, Hrd1
Species Mouse
Gene Type protein-coding
Description synovial apoptosis inhibitor 1, synoviolin
Other Description E3 ubiquitin-protein ligase synoviolin|synoviolin 1
Swissprots Q9DBY1 Q8CGB5 Q80T88
Accessions EDL33194 EDL33195 EDL33196 Q9DBY1 AK004688 BAB23474 AK122558 BAC65840 AK143720 AK172097 AK190544 AK193174 AK194583 AK200543 BB676375 BC032931 BC042199 AAH42199 BC046829 AAH46829 BC057917 AAH57917 BC080722 AAH80722 CD349490 XM_006531850 XP_006531913 NM_001164709 NP_001158181 NM_028769 NP_083045
Function Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. Required for embryogenesis. {ECO:0000269|PubMed:12975321, ECO:0000269|PubMed:15611074, ECO:0000269|PubMed:17170702}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:17059562}; Multi-pass membrane protein {ECO:0000269|PubMed:17059562}.
Tissue Specificity Ubiquitously expressed, with highest levels in bone, spleen, lung and testis. In the brain, present in neurons but not in glial cells. Up-regulated in synovial tissues from mice with collagen-induced arthritis (at protein level). {ECO:0000269|PubMed:12975321, ECO:0000269|PubMed:17059562}.
Top Pathways Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum

Synoviolin CRISPR/Cas9 KO Plasmid (m) - sc-428739 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Synoviolin HDR Plasmid (m) - sc-428739-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Synoviolin Double Nickase Plasmid (m) - sc-428739-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Synoviolin Double Nickase Plasmid (m2) - sc-428739-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Synoviolin CRISPR Activation Plasmid (m) - sc-428739-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Synoviolin CRISPR Activation Plasmid (m2) - sc-428739-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Synoviolin Lentiviral Activation Particles (m) - sc-428739-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Synoviolin Lentiviral Activation Particles (m2) - sc-428739-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Synoviolin siRNA (m) - sc-76621 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Synoviolin shRNA Plasmid (m) - sc-76621-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Synoviolin shRNA (m) Lentiviral Particles - sc-76621-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU022221 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN42401 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND42401 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SYVN1 siRNA (Mouse) - CRM9127 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

SYVN1 - MBS8234951 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse SYVN1 (NM_028769.5) - SHH422180 from Creative biogene

Category siRNA
Species Reactivities Mouse

SYVN1 shRNA Plasmid (Mouse) - CHM9127 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse
Search more