Gene Symbol | MYOT |
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Entrez Gene | 9499 |
Alt Symbol | LGMD1, LGMD1A, MFM3, TTID, TTOD |
Species | Human |
Gene Type | protein-coding |
Description | myotilin |
Other Description | 57 kDa cytoskeletal protein|myofibrillar titin-like Ig domains protein|titin immunoglobulin domain protein (myotilin) |
Swissprots | Q9UBF9 B4DT79 A0A4R6 |
Accessions | AAU05612 EAW62177 EAW62178 Q9UBF9 AF133820 AAD29051 AF144477 AAD44754 AK300076 BAG61880 AK300088 BAG61891 AK307620 AK312733 BAG35604 BC005376 AAH05376 DA896167 EU176357 ABW03808 GQ129442 ACT64576 GQ129443 ACT64577 NM_001135940 NP_001129412 NM_001300911 NP_001287840 NM_006790 NP_006781 |
Function | Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells. {ECO:0000269|PubMed:12499399}. |
Subcellular Location | Cell membrane, sarcolemma. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Sarcomeric, also localized to the sarcolemma. Colocalizes with MYOZ1 at the Z-lines in skeletal muscle. |
Tissue Specificity | Expressed in skeletal muscle (at protein level). Expressed in skeletal muscle, heart, bone marrow and thyroid gland. {ECO:0000269|PubMed:10369880, ECO:0000269|PubMed:10486214}. |
Myotilin CRISPR/Cas9 KO Plasmid (h) - sc-406960 from Santa Cruz Biotechnology
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Myotilin HDR Plasmid (h) - sc-406960-HDR from Santa Cruz Biotechnology
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Myotilin Double Nickase Plasmid (h) - sc-406960-NIC from Santa Cruz Biotechnology
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Myotilin Double Nickase Plasmid (h2) - sc-406960-NIC-2 from Santa Cruz Biotechnology
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Myotilin CRISPR Activation Plasmid (h) - sc-406960-ACT from Santa Cruz Biotechnology
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Myotilin CRISPR Activation Plasmid (h2) - sc-406960-ACT-2 from Santa Cruz Biotechnology
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Myotilin Lentiviral Activation Particles (h) - sc-406960-LAC from Santa Cruz Biotechnology
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Myotilin Lentiviral Activation Particles (h2) - sc-406960-LAC-2 from Santa Cruz Biotechnology
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Myotilin siRNA (h) - sc-43408 from Santa Cruz Biotechnology
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Myotilin shRNA Plasmid (h) - sc-43408-SH from Santa Cruz Biotechnology
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Myotilin shRNA (h) Lentiviral Particles - sc-43408-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU016641 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14877 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14877 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04195 from Sigma-Aldrich
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MYOT siRNA (Human) - CRH6308 from Cohesion Biosciences
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Myotilin CRISPR/Cas9 KO Plasmid (h2) - sc-406960-KO-2 from Santa Cruz Biotechnology
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Myotilin HDR Plasmid (h2) - sc-406960-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human MYOT (NM_006790.2) - SHH348452 from Creative biogene
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Human MYOT siRNA - orb266810 from Biorbyt
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MYOT shRNA Plasmid (Human) - CHH6308 from Cohesion Biosciences
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MYOT miRNA 3'UTR clone - MiUTR3H-06545 from Creative biogene
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MYOT miRNA 3'UTR clone - MiUTR3H-06546 from Creative biogene
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