| Gene Symbol |
PLXNA4
|
| Entrez Gene |
91584
|
| Alt Symbol |
FAYV2820, PLEXA4, PLXNA4A, PLXNA4B, PRO34003
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
plexin A4
|
| Other Description |
plexin-A4
|
| Swissprots |
A4D1N6 Q8NEN3 Q8N969 Q9NTD4 Q6UWC6 Q6ZW89 Q8ND00 Q9HCM2 E9PAM2
|
| Accessions |
EAL24076 EAL24077 EAW83793 EAW83794 EAW83795 EAW83796 Q9HCM2 AA253415 AB046770 BAB13376 AK055487 AK057743 AK091538 AK092345 AK095606 BAC04587 AK123428 BAC85615 AL137352 CAB70707 AL834504 CAD39161 AY358850 AAQ89209 BC028744 AAH28744 CD243425 DR003088 HQ448306 ADQ32786 XM_005250686 XP_005250743 XM_005250687 XP_005250744 XM_006716171 XP_006716234 XM_011516676 XP_011514978 XR_927546 NM_001105543 NP_001099013 NM_020911 NP_065962 NM_181775 NP_861440
|
| Function |
Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
![Western Blot: Plexin A4 Overexpression Lysate (Adult Normal) [NBP2-11421] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Plexin A4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2019_Plexin%2520A4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-11421-img0001.jpg)
![Western Blot: Plexin A4 Overexpression Lysate (Adult Normal) [NBP2-11270] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Plexin A4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7436_Plexin%2520A4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-11270-img0001.jpg)