DCLRE1C

Gene Symbol	DCLRE1C
Entrez Gene	64421
Alt Symbol	A-SCID, DCLREC1C, RS-SCID, SCIDA, SNM1C
Species	Human
Gene Type	protein-coding
Description	DNA cross-link repair 1C
Other Description	DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae)|SNM1 homolog C|SNM1-like protein|protein artemis|severe combined immunodeficiency, type a (Athabascan)
Swissprots	Q9HAM4 Q9BVW9 D3DRT6 Q5JSR5 Q8N132 Q6PK14 Q8TBW9 Q8N101 Q96SD1 Q5JSR4 Q5JSR7 Q5JSR9 Q1HCL2 Q5JSR8 Q5JSS0 Q5JSS7
Accessions	ABF47101 EAW86248 EAW86249 EAW86250 EAW86251 EAW86252 Q96SD1 AF088055 AF395747 AAM53255 AF395748 AAM53256 AF395749 AAM53257 AF395750 AAM53258 AF395751 AAM53259 AF395752 AAM53260 AJ296101 CAC37570 AK021422 BAB13820 AK022922 BAG51137 AK093757 BAG52759 AK290598 BAF83287 AK307912 AW954867 BC000863 AAH00863 BC009185 AAH09185 BC022254 AAH22254 BC067233 BC108276 BE799340 BQ932042 BX648858 XM_006717491 XP_006717554 XM_011519616 XP_011517918 XM_011519617 XP_011517919 XM_011519618 XP_011517920 XM_011519619 XP_011517921 XM_011519620 XP_011517922 XM_011519621 XP_011517923 XR_242702 XR_930514 XR_930515 NM_001033855 NP_001029027 NM_001033857 NP_001029029 NM_001033858 NP_001029030 NM_001289076 NP_001276005 NM_001289077 NP_001276006 NM_001289078 NP_001276007 NM_001289079 NP_001276008 NM_022487 NP_071932 NR_110297
Function	Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation
Subcellular Location	Nucleus {ECO:0000269|PubMed:12055248, ECO:0000269|PubMed:15071507}.
Tissue Specificity	Ubiquitously expressed, with highest levels in the kidney, lung, pancreas and placenta (at the mRNA level). Expression is not increased in thymus or bone marrow, sites of V(D)J recombination. {ECO:0000269|PubMed:11336668}.
Top Pathways	Primary immunodeficiency, Non-homologous end-joining

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Artemis full length protein - ab153486 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human Artemis peptide - ab35688 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human Artemis protein fragment - ab153487 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

DCLRE1C / Artemis Antibody Blocking Peptide - LS-E18417 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DCLRE1C / Artemis Antibody Blocking Peptide - LS-E18418 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DCLRE1C / Artemis Antibody Blocking Peptide - LS-E10288 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Artemis Protein - H00064421-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human Artemis Protein - H00064421-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DCLRE1C-Antibody-N-term-Blocking-Peptide - BP9737a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DCLRE1C Blocking Peptide - 33R-8799 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DCLRE1C Blocking Peptide - 33R-8724 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Artemis - H00064421-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

Artemis - H00064421-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Artemis - H00064421-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

DCLRE1C fusion protein - ag2343 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Artemis (pS516) Blocking Peptide - CBP2758 from Cohesion Biosciences Category Peptide Prices $150.00, $450.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

p-Artemis (S516) Peptide - BS4644P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Protein artemis(DCLRE1C) - CSB-YP857026HU CSB-EP857026HU CSB-BP857026HU CSB-MP857026HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Artemis Blocking Peptide - 3307BP-50 from Biovision Category Peptide Prices $95.00 Sizes 50 μg

Protein artemis (DCLRE1C), Recombinant Protein - MBS1290900 from MyBioSource Category Protein Prices $1,495.00, $1,495.00, $1,725.00, $1,725.00, $2,560.00, $2,560.00, $3,000.00, $3,000.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Artemis, Peptide - MBS843920 from MyBioSource Category Peptide Prices $165.00 Sizes 50 µg

DCLRE1C Peptide, Human - M34GP04089H from Creative Peptides Category Peptide Source Synthetic. Species Human

Artemis Recombinant Protein Antigen - NBP2-56362PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Recombinant Human DCLRE1C Protein, GST-tagged - DCLRE1C-2396H from Creative Biomart Category Protein Source Wheat Germ Species Human

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