Gene Symbol | UBE2E1 |
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Entrez Gene | 7324 |
Alt Symbol | UBCH6 |
Species | Human |
Gene Type | protein-coding |
Description | ubiquitin-conjugating enzyme E2E 1 |
Other Description | ubiquitin carrier protein E1|ubiquitin-conjugating enzyme E2 E1|ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)|ubiquitin-conjugating enzyme E2E 1 (homologous to yeast UBC4/5)|ubiquitin-protein ligase E1 |
Swissprots | K4DI90 P51965 C9J8K2 B2RBX4 |
Accessions | EAW64329 EAW64330 EAW64331 EAW64332 EAW64333 P51965 AK295354 BAH12042 AK314854 BAG37371 BC009139 AAH09139 BF698653 BI223271 DB478686 DB499676 X92963 CAA63539 XM_005265431 XP_005265488 NM_001202476 NP_001189405 NM_003341 NP_003332 NM_182666 NP_872607 |
Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. {ECO:0000269|PubMed:16428300, ECO:0000269|PubMed:20061386}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:18845142}. |
Top Pathways | Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum |
UBE2E1 CRISPR/Cas9 KO Plasmid (h) - sc-407293 from Santa Cruz Biotechnology
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UBE2E1 HDR Plasmid (h) - sc-407293-HDR from Santa Cruz Biotechnology
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UBE2E1 Double Nickase Plasmid (h) - sc-407293-NIC from Santa Cruz Biotechnology
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UBE2E1 Double Nickase Plasmid (h2) - sc-407293-NIC-2 from Santa Cruz Biotechnology
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UBE2E1 CRISPR Activation Plasmid (h) - sc-407293-ACT from Santa Cruz Biotechnology
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UBE2E1 CRISPR Activation Plasmid (h2) - sc-407293-ACT-2 from Santa Cruz Biotechnology
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UBE2E1 Lentiviral Activation Particles (h) - sc-407293-LAC from Santa Cruz Biotechnology
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UBE2E1 Lentiviral Activation Particles (h2) - sc-407293-LAC-2 from Santa Cruz Biotechnology
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UBE2E1 siRNA (h) - sc-61744 from Santa Cruz Biotechnology
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UBE2E1 shRNA Plasmid (h) - sc-61744-SH from Santa Cruz Biotechnology
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UBE2E1 shRNA (h) Lentiviral Particles - sc-61744-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU074321 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22361 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22361 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06304 from Sigma-Aldrich
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UBE2E1 siRNA (Human) - CRH5007 from Cohesion Biosciences
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UBE2E1 - MBS8205726 from MyBioSource
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shRNA set against Human UBE2E1 (NM_182666.2) - SHH438932 from Creative biogene
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shRNA set against Human UBE2E1(NM_003341.4) - SHL110646 from Creative biogene
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shRNA set against Human UBE2E1(NM_001202476.1) - SHL110754 from Creative biogene
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shRNA set against Human UBE2E1(NM_003341.4) - SHL110772 from Creative biogene
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UBE2E1 shRNA Plasmid (Human) - CHH5007 from Cohesion Biosciences
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UBE2E1 miRNA 3'UTR clone - MiUTR1H-10944 from Creative biogene
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UBE2E1 miRNA 3'UTR clone - MiUTR1H-10945 from Creative biogene
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UBE2E1 miRNA 3'UTR clone - MiUTR3H-05411 from Creative biogene
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