| Gene Symbol |
DPH2
|
| Entrez Gene |
1802
|
| Alt Symbol |
DPH2L2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DPH2 homolog (S. cerevisiae)
|
| Other Description |
DPH2-like 2|diphthamide biosynthesis protein 2|diphthamide biosynthesis protein 2 homolog-like 2|diphthamide biosynthesis-like protein 2|diptheria toxin resistance protein required for diphthamide biosynthesis-like 2
|
| Swissprots |
B2RDE3 A8MVC9 B4DNI8 O60623 Q9BQC3
|
| Accessions |
EAX07070 EAX07071 Q9BQC3 AA252672 AF053003 AAC18086 AK091303 BAG52330 AK297933 BAG60250 AK315506 BAG37890 BC001389 AAH01389 BC003181 AAH03181 BC016956 AAH16956 BM794530 BQ215136 BT007431 AAP36099 BX362196 XM_005270559 XP_005270616 XM_011540866 XP_011539168 XM_011540867 XP_011539169 NM_001039589 NP_001034678 NM_001384 NP_001375 NM_201399
|
| Function |
Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). {ECO:0000250}.
|
| Tissue Specificity |
Strongly expressed in skeletal muscle. Moderately expressed in heart, small intestine, liver, pancreas, testis and colon. Weakly expressed in brain, placenta, kidney, spleen, thymus, prostate, ovary and lymphocytes. {ECO:0000269|PubMed:9782084}.
|