| Gene Symbol |
ADRA1A
|
| Entrez Gene |
148
|
| Alt Symbol |
ADRA1C, ADRA1L1, ALPHA1AAR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adrenoceptor alpha 1A
|
| Other Description |
G protein coupled receptor|adrenergic, alpha-1A-, receptor variant 1|adrenergic, alpha-1A-, receptor variant 11|adrenergic, alpha-1A-, receptor variant 3|adrenergic, alpha-1A-, receptor variant 5|adrenergic, alpha-1A-, receptor variant 8|alpha-1A adrenergic receptor|alpha-1A adrenoceptor|alpha-1A adrenoreceptor|alpha-1C adrenergic receptor
|
| Swissprots |
Q9UD67 Q96RE8 B0ZBD5 A8K0I3 Q6RUJ4 O60451 B0ZBD6 B0ZBD2 P35348 B0ZBD8 Q6RUJ9 Q13675 Q6RUJ7 Q4VBM7 Q9UD63 B0ZBD9 Q13729 Q6RUJ8 B0ZBD4 B0ZBD1 Q6RUJ5
|
| Accessions |
AAA18783 AAB60353 AAQ91331 ACA05899 ACA05901 ACA05903 ACA05905 ACA05907 BAC05926 CAC39680 CAC39900 CAD69352 EAW63569 EAW63570 EAW63571 EAW63572 P35348 AF013261 AAC06138 AF395806 AAK77197 AK289548 BAF82237 AK311558 AY491775 AAR84644 AY491776 AAR84645 AY491777 AAR84646 AY491778 AAR84647 AY491780 AAR84649 AY491781 AAR84650 BC095512 AAH95512 D25235 BAA04960 D32201 BAA06900 D32202 BAA06901 L31774 AAB59486 S76001 AAD14205 U02569 AAA93114 XM_005273414 XP_005273471 XM_006716292 XP_006716355 XM_006716293 XP_006716356 XM_011544411 XP_011542713 XM_011544412 XP_011542714 NM_000680 NP_000671 NM_033302 NP_150645 NM_033303 NP_150646 NM_033304 NP_150647
|
| Function |
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}.
|
| Subcellular Location |
Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.
|
| Tissue Specificity |
Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart. {ECO:0000269|PubMed:7737411, ECO:0000269|PubMed:8196478, ECO:0000269|PubMed:9490024}.
|
| Top Pathways |
Calcium signaling pathway, Vascular smooth muscle contraction, Salivary secretion, Adrenergic signaling in cardiomyocytes, cGMP-PKG signaling pathway
|
