| Gene Symbol |
NAALAD2
|
| Entrez Gene |
10003
|
| Alt Symbol |
GCPIII, GPCIII, NAADALASE2, NAALADASE2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
N-acetylated alpha-linked acidic dipeptidase 2
|
| Other Description |
N-acetylated alpha-linked acidic dipeptidase II|N-acetylated-alpha-linked acidic dipeptidase 2|N-acetylated-alpha-linked acidic dipeptidase II|NAALADase II|glutamate carboxypeptidase III
|
| Swissprots |
Q4KKV4 B3KQR4 Q9Y3Q0 Q4VAM9
|
| Accessions |
CAC39719 CAI72090 EAW66865 Q9Y3Q0 AJ012370 CAB39967 AK075390 BAG52126 AL133614 AY010115 BC027594 AAH27594 BC038840 AAH38840 BC067793 BC096316 AAH96316 BC096317 AAH96317 BC096318 AAH96318 BC099646 AAH99646 BU618706 CN355388 XM_005273701 XP_005273758 XM_011542550 XP_011540852 XM_011542551 XP_011540853 XM_011542552 XP_011540854 XM_011542553 XP_011540855 XM_011542554 XP_011540856 NM_001300930 NP_001287859 NM_005467 NP_005458
|
| Function |
Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivate the peptide neurotransmitter N- acetylaspartylglutamate. {ECO:0000269|PubMed:10085079}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Highest expression in the testis. Also found in ovary and spleen. Weak expression in prostate, heart and placenta. In brain, expressed in striatum, parietal cortex and ventral striatum with lower levels in hippocampus, brain stem, putamen and superior colliculus.
|
![Western Blot: NAALAD2 Overexpression Lysate (Adult Normal) [NBP2-07747] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NAALAD2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/15582_NAALAD2%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-07747-img0001.jpg)