| Gene Symbol |
SYTL2
|
| Entrez Gene |
54843
|
| Alt Symbol |
CHR11SYT, EXO4, PPP1R151, SGA72M, SLP2, SLP2A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
synaptotagmin-like 2
|
| Other Description |
breast cancer-associated antigen SGA-72M|chromosome 11 synaptotagmin|exophilin-4|protein phosphatase 1, regulatory subunit 151|synaptotagmin-like protein 2
|
| Swissprots |
B4DQ26 B7SA85 Q6ZN59 B7ZLX7 B7ZLX6 Q96BJ2 Q2YDA7 B3KRS3 Q6ZVC5 Q6TV07 Q9NXM1 Q9H768 Q8ND34 B4DJT5 B4DKW3 Q9HCH5
|
| Accessions |
CAF86787 EAW75107 EAW75108 EAW75109 EAW75110 EAW75111 EAW75112 EAW75113 Q9HCH5 AB046817 BAB13423 AI928445 AJ303364 CAC33886 AK000170 BAA90989 AK024872 BAB15030 AK056722 AK074737 BAC11170 AK092121 BAG52485 AK124754 BAC85937 AK127504 BAC87010 AK131365 BAD18516 AK222707 AK222710 AK296224 BAG58947 AK296740 BAG59325 AK298604 BAG60788 AL601023 AL706957 AL834422 CAD39083 AY386362 AAR25619 BC015540 AAH15540 BC068495 BC110315 AAI10316 BC136450 AAI36451 BC144114 AAI44115 BC144115 AAI44116 BQ308382 BX427706 BX647671 BX648068 CB046277 DA282196 DA344600 DA378461 DA449325 DC348081 EU035829 ABV82746 HQ447815 ADQ32299 XM_005274057 XP_005274114 XM_005274060 XP_005274117 XM_005274061 XP_005274118 XM_005274062 XP_005274119 XM_005274063 XP_005274120 XM_005274066 XP_005274123 XM_005274067 XP_005274124 XM_011545105 XP_011543407 XM_011545106 XP_011543408 XM_011545107 XP_011543409 XM_011545108 XP_011543410 XM_011545109 XP_011543411 XM_011545110 XP_011543412 XM_011545111 XP_011543413 XM_011545112 XP_011543414 XM_011545113 XP_011543415 XM_011545114 XP_011543416 XM_011545115 XP_011543417 XM_011545116 XP_011543418 NM_001162951 NP_001156423 NM_001162952 NP_001156424 NM_001162953 NP_001156425 NM_001289608 NP_001276537 NM_001289609 NP_001276538 NM_001289610 NP_001276539 NM_032943 NP_116561 NM_206929 NP_996812 NM_206930 NP_996813 NM_032379 NM_206927 NM_206928
|
| Function |
Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol- 4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon- containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}.
|
| Subcellular Location |
Isoform 1: Cytoplasm. Cell membrane. Note=Recruited on vesicular structures in cytotoxic T-lymphocytes (CTL) by RAB27A.
|
| Tissue Specificity |
Isoform 1 is expressed in hematopoietic lineages with a strong expression in CD4 and CD8 T-lymphocytes. It is also widely expressed in nonhematopoietic tissues. Isoform 5 is expressed only in nonhematopoietic tissues. Isoform 4 is expressed in pancreatic alpha cells. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}.
|
