Gene Symbol | Nfkb1 |
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Entrez Gene | 18033 |
Alt Symbol | NF-KB1, NF-kappaB, NF-kappaB1, p105, p50, p50/p105 |
Species | Mouse |
Gene Type | protein-coding |
Description | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 |
Other Description | DNA-binding factor KBF1|EBP-1|NF kappaB1|NF-kappa-B1 p84/NF-kappa-B1 p98|NF-kappaB p50|nuclear factor NF-kappa-B p105 subunit|nuclear factor kappaB p50|nuclear factor of kappa light chain gene enhancer in B-cells 1, p105|nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105|nuclear factor-kappaB p50|p50 subunit of NF kappaB|p50 subunit of NF-kappaB |
Swissprots | Q3V2V6 Q8C712 Q80Y21 P25799 Q3TZE8 Q75ZL1 B2RRQ6 Q6TDG8 |
Accessions | EDL12139 EDL12140 EDL12141 EDL12142 EDL12143 P25799 AB119195 BAC84979 AB221614 AK036827 AK048506 AK052726 BAC35117 AK089660 BAE43399 AK146389 AK157915 BAE34261 AK158020 AK159423 AW907469 AY423849 AAR00341 AY521462 AAS00547 AY521463 AAS00548 BC050841 AAH50841 BC138535 AAI38536 BC138536 AAI38537 BC145317 L13466 AAC37644 L28117 L28118 M57999 AAA40415 S66656 AAB28573 S89033 AAB21851 XM_006501106 XP_006501169 XM_006501107 XP_006501170 NM_008689 NP_032715 |
Function | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with ot |
Subcellular Location | Isoform 6: Nucleus. Cytoplasm. |
Top Pathways | Apoptosis, cAMP signaling pathway, Viral carcinogenesis, PI3K-Akt signaling pathway, Inflammatory bowel disease (IBD) |
NF-κB1 p105/p50 (D4P4D) Rabbit mAb - 13586 from Cell Signaling Technology
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NFκB p50 (D-17) - sc-1192 from Santa Cruz Biotechnology
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Anti-NFkB p105 / p50 antibody - ab19285 from Abcam
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ABL1 antibody (Thr735) - 70R-32627 from Fitzgerald
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ABL1 antibody - 70R-31552 from Fitzgerald
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NFKP p105/p50 antibody - 70R-34291 from Fitzgerald
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NFKP p105/p50 antibody - 70R-34301 from Fitzgerald
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NFkB p105/p50 antibody - 70R-37457 from Fitzgerald
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NFKB p105/p50 antibody (Ser927) - 70R-30594 from Fitzgerald
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Anti -CD40 (CD40 Antigen, B Cell Surface Antigen CD40, Bp50, CD40L Receptor, TumorNecrosis Factor Receptor Superfamily Member 5, TNF Receptor Superfamily Member 5, TNFRSF5) - C2392-02T from USBiological Life Science
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NFkB p105/p50 antibody (Ser927) - 70R-37361 from Fitzgerald
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NFkB p105 antibody (Ser932) - 70R-37312 from Fitzgerald
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NFKB p105 antibody - 70R-35682 from Fitzgerald
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NFKP p105/p50 antibody (Ser932) - 70R-34290 from Fitzgerald
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NFKP p105/p50 antibody (Ser337) - 70R-34300 from Fitzgerald
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NFKB p105/p50 antibody - 70R-30595 from Fitzgerald
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NFKB1 Antibody - abx114173 from Abbexa
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NF-kB p105 / p50 antibody - PAB11969 from Acris Antibodies
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Anti-NFkB p105/p50 Antibody - 10-P2111-1 from ARP American Research Products
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Anti-Nuclear Factor Kappa B (NFkB) - 20-4150 from ARP American Research Products
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Anti-Nuclear Factor Kappa B (NFkB) - 20-4151 from ARP American Research Products
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NFkB p105/p50, Polyclonal Antibody - MBS176369 from MyBioSource
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CD40 Antibody - TGB-327 from Reagent Proteins
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CD40 Antibody, Biotin - TGB-329 from Reagent Proteins
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CD40 Antibody, FITC - TGB-328 from Reagent Proteins
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