Gene Symbol | GUCY2F |
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Entrez Gene | 2986 |
Alt Symbol | CYGF, GC-F, GUC2DL, GUC2F, RETGC-2, ROS-GC2 |
Species | Human |
Gene Type | protein-coding |
Description | guanylate cyclase 2F, retinal |
Other Description | guanylate cyclase 2D-like, membrane (retina-specific)|guanylate cyclase F|retinal guanylyl cyclase 2|rod outer segment membrane guanylate cyclase 2 |
Swissprots | P51841 Q9UJF1 |
Accessions | EAX02681 P51841 BC144241 BC156674 AAI56675 L37378 AAA74451 XR_244473 NM_001522 NP_001513 |
Function | Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Specificity | Retina. Localized exclusively in the outer nuclear layer and inner segments of the rod and cone photoreceptor cells. |
Top Pathways | Phototransduction, Purine metabolism |
ROS-GC2 CRISPR/Cas9 KO Plasmid (h) - sc-410809 from Santa Cruz Biotechnology
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ROS-GC2 HDR Plasmid (h) - sc-410809-HDR from Santa Cruz Biotechnology
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ROS-GC2 Double Nickase Plasmid (h) - sc-410809-NIC from Santa Cruz Biotechnology
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ROS-GC2 Double Nickase Plasmid (h2) - sc-410809-NIC-2 from Santa Cruz Biotechnology
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ROS-GC2 CRISPR Activation Plasmid (h) - sc-410809-ACT from Santa Cruz Biotechnology
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ROS-GC2 CRISPR Activation Plasmid (h2) - sc-410809-ACT-2 from Santa Cruz Biotechnology
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ROS-GC2 Lentiviral Activation Particles (h) - sc-410809-LAC from Santa Cruz Biotechnology
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ROS-GC2 Lentiviral Activation Particles (h2) - sc-410809-LAC-2 from Santa Cruz Biotechnology
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ROS-GC2 siRNA (h) - sc-45441 from Santa Cruz Biotechnology
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ROS-GC2 shRNA Plasmid (h) - sc-45441-SH from Santa Cruz Biotechnology
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ROS-GC2 shRNA (h) Lentiviral Particles - sc-45441-V from Santa Cruz Biotechnology
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GUCY2F RNAi - H00002986-R04 from Novus Biologicals
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MISSION® siRNA - SIHK0883 from Sigma-Aldrich
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MISSION® siRNA - SIHK0881 from Sigma-Aldrich
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MISSION® siRNA - SIHK0882 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1993 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1993 from Sigma-Aldrich
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GUCY2F siRNA (Human) - CRH2024 from Cohesion Biosciences
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GUCY2F - MBS8213393 from MyBioSource
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GUCY2F shRNA Plasmid (Human) - CHH2024 from Cohesion Biosciences
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