GSAP

Gene Symbol	GSAP
Entrez Gene	54103
Alt Symbol	PION
Species	Human
Gene Type	protein-coding
Description	gamma-secretase activating protein
Other Description	gamma-secretase-activating protein|pigeon homolog|protein pigeon homolog
Swissprots	Q9UMH3 Q9Y4L9 A4D1B6 Q8ND73 Q3MJC0 A4D1B5
Accessions	A4D1B5 EAL24201 AK026696 AK026747 AK027188 AK126364 AL079277 CAB45152 AL079297 CAB45193 AL834358 CAD39023 BC101499 AAI01500 BC110797 BC143549 AAI43550 BM842423 DB498013 XM_011516325 XP_011514627 XM_011516326 XP_011514628 XM_011516327 XP_011514629 XM_011516328 XP_011514630 XM_011516329 XP_011514631 XM_011516330 XP_011514632 XM_011516331 XP_011514633 XM_011516332 XP_011514634 XR_927479 NM_017439 NP_059135
Function	Regulator of gamma-secretase activity, which specifically activates the production of beta-amyloid protein (beta-amyloid protein 40 and beta-amyloid protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate beta- amyloid, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD. {ECO:0000269|PubMed:20811458}.
Subcellular Location	Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:20811458}.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:20811458}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GSAP / PION Antibody Blocking Peptide - LS-E1708 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GSAP / PION Antibody Blocking Peptide - LS-E31066 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PION-Antibody-C-term-Blocking-peptide - BP12480b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human gSAP Protein - abx066750 from Abbexa Category Protein Source E.coli Species Human

PION / GSAP control peptide - AP26090CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

PION Peptide - 6161P from ProSci Category Peptide Species Human

PION fusion protein - ag20241 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

PION fusion protein - ag20101 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Gamma-Secretase Activating Protein (gSAP) - RPR761Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Gamma-Secretase Activating Protein (gSAP) - RPR761Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Gamma-Secretase Activating Protein (gSAP) - RPR761Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Gamma-secretase-activating protein(PION) - CSB-YP018019HU CSB-EP018019HU CSB-BP018019HU CSB-MP018019HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

GSAP Blocking Peptide - 3308BP-50 from Biovision Category Peptide Prices $95.00 Sizes 50 μg

GSAP, Peptide - MBS843742 from MyBioSource Category Peptide Prices $165.00 Sizes 50 µg

GSAP Protein - NBP1-89582PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

GSAP Protein - NBP1-89581PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

PION Peptide, Human - M34GP11804H from Creative Peptides Category Peptide Source Synthetic. Species Human

Gamma-Secretase Activating Protein (gSAP), Recombinant Protein - MBS2018575 from MyBioSource Category Protein Prices $185.00, $385.00, $595.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Gamma-secretase-activating protein (PION), Recombinant Protein - MBS1184872 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

GSAP Recombinant Protein (OPCD03710) - OPCD03710 from Aviva Systems Biology Category Protein Source E.coli Species Human

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