| Gene Symbol |
SLC16A7
|
| Entrez Gene |
9194
|
| Alt Symbol |
MCT2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 16 (monocarboxylate transporter), member 7
|
| Other Description |
monocarboxylate transporter 2|solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
|
| Swissprots |
Q9UPB3 O60669 Q8NEM3
|
| Accessions |
EAW97096 EAW97097 EAW97098 EAW97099 O60669 AF049608 AAC70919 AF058056 AAC13721 AK301725 BAG63191 AK310281 AK313345 BAG36148 BC007463 BC030693 AAH30693 DC394954 DQ893579 ABM84505 DQ894758 ABM85684 DR000391 XM_005269231 XP_005269288 XM_011538989 XP_011537291 XM_011538990 XP_011537292 XM_011538991 XP_011537293 XM_011538992 XP_011537294 XM_011538993 XP_011537295 XM_011538994 XP_011537296 XM_011538995 XP_011537297 XM_011538996 XP_011537298 XM_011538997 XP_011537299 NM_001270622 NP_001257551 NM_001270623 NP_001257552 NM_004731 NP_004722 NR_073055 NR_073056
|
| Function |
Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter. {ECO:0000269|PubMed:9786900}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:15505343, ECO:0000269|PubMed:9786900}; Multi-pass membrane protein {ECO:0000269|PubMed:15505343, ECO:0000269|PubMed:9786900}.
|
| Tissue Specificity |
Detected in heart and in blood lymphocytes and monocytes (at protein level). High expression in testis, moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain and Leukocyte. Restricted expression in normal tissues, but widely expressed in cancer cells. {ECO:0000269|PubMed:15505343}.
|