| Gene Symbol | BANP |
|---|---|
| Entrez Gene | 54971 |
| Alt Symbol | BEND1, SMAR1, SMARBP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | BTG3 associated nuclear protein |
| Other Description | BEN domain-containing protein 1|protein BANP|scaffold/matrix-associated region-1-binding protein |
| Swissprots | B4DNJ9 Q96GJ7 B2RCF7 A8MU25 A8MX25 Q8N9N5 F5GZM0 Q9NWY1 |
| Accessions | EAW95364 EAW95365 EAW95366 EAW95367 EAW95368 EAW95369 EAW95370 Q8N9N5 AK001039 BAG50850 AK094158 BAC04296 AK125232 BAG54171 AK293472 BAG56965 AK297945 BAG60261 AK315089 BAG37554 AK315535 AL157429 CAB75653 BC009424 AAH09424 BC018247 CN289917 DA632793 DQ893176 ABM84102 DQ896475 ABM87474 T49823 XM_005256008 XP_005256065 XM_005256009 XP_005256066 XM_011523170 XP_011521472 XM_011523171 XP_011521473 XM_011523172 XP_011521474 XM_011523173 XP_011521475 XM_011523174 XP_011521476 XM_011523175 XP_011521477 XM_011523176 XP_011521478 XM_011523177 XP_011521479 XM_011523178 XP_011521480 XM_011523179 XP_011521481 XM_011523180 XP_011521482 XM_011523181 XP_011521483 XM_011523182 XP_011521484 XM_011523183 XP_011521485 XM_011523184 XP_011521486 XM_011523185 XP_011521487 XM_011523186 XP_011521488 XM_011523187 XP_011521489 XR_933350 XR_933352 XR_933353 XR_933355 XR_933356 XR_933357 XR_933358 XR_933359 XR_933360 NM_001173539 NP_001167010 NM_001173540 NP_001167011 NM_001173541 NP_001167012 NM_001173542 NP_001167013 NM_001173543 NP_001167014 NM_017869 NP_060339 NM_079837 NP_524576 |
| Function | Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:16166625}. |
| Tissue Specificity | Down-regulated in breast cancer cell lines. {ECO:0000269|PubMed:16166625}. |