| Gene Symbol |
ATF3
|
| Entrez Gene |
467
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
activating transcription factor 3
|
| Other Description |
cAMP-dependent transcription factor ATF-3|cyclic AMP-dependent transcription factor ATF-3
|
| Swissprots |
Q6ICQ9 Q7Z566 P18847 Q8WYM6 Q5VTZ2
|
| Accessions |
AAQ93358 EAW93383 EAW93384 EAW93385 EAW93386 EAW93387 EAW93388 P18847 AB066566 BAB84092 AB078026 BAC00495 AB078027 BAC00496 AB078028 BAC05510 AB209032 BAD92269 AI492228 AI949953 AK123699 AK125255 AK294296 BAG57579 AK312998 BAG35834 AL560585 AU135799 AY313926 AAP93895 AY313927 AAP93896 BC006322 AAH06322 BI524020 BI819383 BT006996 AAP35642 CD638624 CD641946 CD742713 CR450334 CAG29330 DA589280 DA691940 DB197400 DQ892723 ABM83649 DQ895972 ABM86898 L19871 AAA20506 XM_005273146 XP_005273203 XM_011509579 XP_011507881 NM_001030287 NP_001025458 NM_001040619 NP_001035709 NM_001206484 NP_001193413 NM_001206486 NP_001193415 NM_001206488 NP_001193417 NM_001674 NP_001665 NM_001206485 NM_004024
|
| Function |
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978, ECO:0000269|PubMed:12034827}.
|
| Top Pathways |
HTLV-I infection
|